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Ovarid
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Ovarid Brand names, Ovarid Analogs

Ovarid Brand Names Mixture

  • No information avaliable

Ovarid Chemical_Formula

C7H7NO3

Ovarid RX_link

http://www.rxlist.com/cgi/generic2/canasa.htm

Ovarid fda sheet

Ovarid FDA

Ovarid msds (material safety sheet)

Ovarid MSDS

Ovarid Synthesis Reference

No information avaliable

Ovarid Molecular Weight

153.135 g/mol

Ovarid Melting Point

283 oC

Ovarid H2O Solubility

0.84 g/L at 20°C

Ovarid State

Solid

Ovarid LogP

1.012

Ovarid Dosage Forms

Rectal suppository (500 mg or 1000 mg)

Ovarid Indication

For the treatment of active ulcerative proctitis.

Ovarid Pharmacology

Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.

Ovarid Absorption

20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.

Ovarid side effects and Toxicity

Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.

Ovarid Patient Information

Ovarid Organisms Affected

Humans and other mammals