Ovarid Brand names, Ovarid Analogs
Ovarid Brand Names Mixture
Ovarid fda sheet
Ovarid msds (material safety sheet)
Ovarid Synthesis Reference
No information avaliable
Ovarid Molecular Weight
Ovarid Melting Point
Ovarid H2O Solubility
0.84 g/L at 20°C
Ovarid Dosage Forms
Rectal suppository (500 mg or 1000 mg)
For the treatment of active ulcerative proctitis.
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Ovarid side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Ovarid Patient Information
Ovarid Organisms Affected
Humans and other mammals