Volidan
Volidan Brand names, Volidan Analogs
Volidan Brand Names Mixture
- No information avaliable
Volidan Chemical_Formula
C7H7NO3
Volidan RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Volidan fda sheet
Volidan msds (material safety sheet)
Volidan Synthesis Reference
No information avaliable
Volidan Molecular Weight
153.135 g/mol
Volidan Melting Point
283 oC
Volidan H2O Solubility
0.84 g/L at 20°C
Volidan State
Solid
Volidan LogP
1.012
Volidan Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Volidan Indication
For the treatment of active ulcerative proctitis.
Volidan Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Volidan Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Volidan side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Volidan Patient Information
Volidan Organisms Affected
Humans and other mammals
