PharmacyCodes



Megestrolum [INN-Latin] en es it fr

Megestrolum [INN-Latin] Brand names, Megestrolum [INN-Latin] Analogs

Megestrolum [INN-Latin] Brand Names Mixture

  • No information avaliable

Megestrolum [INN-Latin] Chemical_Formula

C7H7NO3

Megestrolum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic2/canasa.htm

Megestrolum [INN-Latin] fda sheet

Megestrolum_[INN-Latin] FDA

Megestrolum [INN-Latin] msds (material safety sheet)

Megestrolum_[INN-Latin] MSDS

Megestrolum [INN-Latin] Synthesis Reference

No information avaliable

Megestrolum [INN-Latin] Molecular Weight

153.135 g/mol

Megestrolum [INN-Latin] Melting Point

283 oC

Megestrolum [INN-Latin] H2O Solubility

0.84 g/L at 20°C

Megestrolum [INN-Latin] State

Solid

Megestrolum [INN-Latin] LogP

1.012

Megestrolum [INN-Latin] Dosage Forms

Rectal suppository (500 mg or 1000 mg)

Megestrolum [INN-Latin] Indication

For the treatment of active ulcerative proctitis.

Megestrolum [INN-Latin] Pharmacology

Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.

Megestrolum [INN-Latin] Absorption

20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.

Megestrolum [INN-Latin] side effects and Toxicity

Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.

Megestrolum [INN-Latin] Patient Information

Megestrolum [INN-Latin] Organisms Affected

Humans and other mammals