Ovaban
Ovaban Brand names, Ovaban Analogs
Ovaban Brand Names Mixture
- No information avaliable
Ovaban Chemical_Formula
C7H7NO3
Ovaban RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Ovaban fda sheet
Ovaban msds (material safety sheet)
Ovaban Synthesis Reference
No information avaliable
Ovaban Molecular Weight
153.135 g/mol
Ovaban Melting Point
283 oC
Ovaban H2O Solubility
0.84 g/L at 20°C
Ovaban State
Solid
Ovaban LogP
1.012
Ovaban Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Ovaban Indication
For the treatment of active ulcerative proctitis.
Ovaban Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Ovaban Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Ovaban side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Ovaban Patient Information
Ovaban Organisms Affected
Humans and other mammals
