Niagestin
Niagestin Brand names, Niagestin Analogs
Niagestin Brand Names Mixture
- No information avaliable
Niagestin Chemical_Formula
C7H7NO3
Niagestin RX_link
http://www.rxlist.com/cgi/generic2/canasa.htm
Niagestin fda sheet
Niagestin msds (material safety sheet)
Niagestin Synthesis Reference
No information avaliable
Niagestin Molecular Weight
153.135 g/mol
Niagestin Melting Point
283 oC
Niagestin H2O Solubility
0.84 g/L at 20°C
Niagestin State
Solid
Niagestin LogP
1.012
Niagestin Dosage Forms
Rectal suppository (500 mg or 1000 mg)
Niagestin Indication
For the treatment of active ulcerative proctitis.
Niagestin Pharmacology
Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.
Niagestin Absorption
20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.
Niagestin side effects and Toxicity
Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.
Niagestin Patient Information
Niagestin Organisms Affected
Humans and other mammals
