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Megestil Brand names, Megestil Analogs

Megestil Brand Names Mixture

  • No information avaliable

Megestil Chemical_Formula

C7H7NO3

Megestil RX_link

http://www.rxlist.com/cgi/generic2/canasa.htm

Megestil fda sheet

Megestil FDA

Megestil msds (material safety sheet)

Megestil MSDS

Megestil Synthesis Reference

No information avaliable

Megestil Molecular Weight

153.135 g/mol

Megestil Melting Point

283 oC

Megestil H2O Solubility

0.84 g/L at 20°C

Megestil State

Solid

Megestil LogP

1.012

Megestil Dosage Forms

Rectal suppository (500 mg or 1000 mg)

Megestil Indication

For the treatment of active ulcerative proctitis.

Megestil Pharmacology

Sulfasalazine has been used in the treatment of ulcerative colitis for over 55 years. It is split by bacterial action in the colon into sulfapyridine (SP) and mesalamine (5-ASA). It is thought that the mesalamine component only is therapeutically active in ulcerative colitis.

Megestil Absorption

20 to 30% absorbed following oral administration. 10 to 35% absorbed from the colon (rectal suppository) - extent of absorption is determined by the length of time the drug is retained in the colon.

Megestil side effects and Toxicity

Oral, mouse: LD50 = 3370 mg/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = >5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalamine absorption from the colon is limited.

Megestil Patient Information

Megestil Organisms Affected

Humans and other mammals