Mentax
Category
Mentax Brand names, Mentax Analogs
Mentax Brand Names Mixture
No information avaliable
Mentax Chemical_Formula
C23H27N
Mentax RX_link
http://www.rxlist.com/cgi/generic2/butenafine.htm
Mentax fda sheet
Mentax msds (material safety sheet)
Mentax Synthesis Reference
No information avaliable
Mentax Molecular Weight
317.467 g/mol
Mentax Melting Point
No information avaliable
Mentax H2O Solubility
Slightly soluble (HCl salt)
Mentax State
Solid
Mentax LogP
7.12
Mentax Dosage Forms
Cream (10 mg drug per gram of cream)
Mentax Indication
For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.
Mentax Pharmacology
Butenafine is an antifungal agent that acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. It is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.
Mentax Absorption
The total amount absorbed through the skin into the systemic circulation has not been quantified.
Mentax Toxicity
No information avaliable
Mentax Patient Information
Mentax Organisms Affected
Fungi
