Butenafine HCL
Category
Butenafine HCL Brand names, Butenafine HCL Analogs
Butenafine HCL Brand Names Mixture
Butenafine HCL Chemical_Formula
C23H27N
Butenafine HCL RX_link
http://www.rxlist.com/cgi/generic2/butenafine.htm
Butenafine HCL fda sheet
Butenafine HCL msds (material safety sheet)
Butenafine HCL Synthesis Reference
No information avaliable
Butenafine HCL Molecular Weight
317.467 g/mol
Butenafine HCL Melting Point
No information avaliable
Butenafine HCL H2O Solubility
Slightly soluble (HCl salt)
Butenafine HCL State
Solid
Butenafine HCL LogP
7.12
Butenafine HCL Dosage Forms
Cream (10 mg drug per gram of cream)
Butenafine HCL Indication
For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.
Butenafine HCL Pharmacology
Butenafine is an antifungal agent that acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. It is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.
Butenafine HCL Absorption
The total amount absorbed through the skin into the systemic circulation has not been quantified.
Butenafine HCL Toxicity
No information avaliable
Butenafine HCL Patient Information
Butenafine HCL Organisms Affected
Fungi
