Butenafine_HCL
Category
Butenafine_HCL Brand names, Butenafine_HCL Analogs
Butenafine_HCL Brand Names Mixture
No information avaliable
Butenafine_HCL Chemical_Formula
C23H27N
Butenafine_HCL RX_link
http://www.rxlist.com/cgi/generic2/butenafine.htm
Butenafine_HCL fda sheet
Butenafine_HCL msds (material safety sheet)
Butenafine_HCL Synthesis Reference
No information avaliable
Butenafine_HCL Molecular Weight
317.467 g/mol
Butenafine_HCL Melting Point
No information avaliable
Butenafine_HCL H2O Solubility
Slightly soluble (HCl salt)
Butenafine_HCL State
Solid
Butenafine_HCL LogP
7.12
Butenafine_HCL Dosage Forms
Cream (10 mg drug per gram of cream)
Butenafine_HCL Indication
For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.
Butenafine_HCL Pharmacology
Butenafine is an antifungal agent that acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. It is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.
Butenafine_HCL Absorption
The total amount absorbed through the skin into the systemic circulation has not been quantified.
Butenafine_HCL Toxicity
No information avaliable
Butenafine_HCL Patient Information
Butenafine_HCL Organisms Affected
Fungi
