Butenafine_hydrochloride
Category
Butenafine_hydrochloride Brand names, Butenafine_hydrochloride Analogs
Butenafine_hydrochloride Brand Names Mixture
No information avaliable
Butenafine_hydrochloride Chemical_Formula
C23H27N
Butenafine_hydrochloride RX_link
http://www.rxlist.com/cgi/generic2/butenafine.htm
Butenafine_hydrochloride fda sheet
Butenafine_hydrochloride msds (material safety sheet)
Butenafine_hydrochloride Synthesis Reference
No information avaliable
Butenafine_hydrochloride Molecular Weight
317.467 g/mol
Butenafine_hydrochloride Melting Point
No information avaliable
Butenafine_hydrochloride H2O Solubility
Slightly soluble (HCl salt)
Butenafine_hydrochloride State
Solid
Butenafine_hydrochloride LogP
7.12
Butenafine_hydrochloride Dosage Forms
Cream (10 mg drug per gram of cream)
Butenafine_hydrochloride Indication
For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.
Butenafine_hydrochloride Pharmacology
Butenafine is an antifungal agent that acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. It is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.
Butenafine_hydrochloride Absorption
The total amount absorbed through the skin into the systemic circulation has not been quantified.
Butenafine_hydrochloride Toxicity
No information avaliable
Butenafine_hydrochloride Patient Information
Butenafine_hydrochloride Organisms Affected
Fungi
