Butenafine_[INN]

Category

Butenafine_[INN]




Useful info

Butenafine_[INN] Brand names, Butenafine_[INN] Analogs

Butenafine_[INN] Brand Names Mixture

  • No information avaliable

    • Butenafine_[INN] Chemical_Formula

    C23H27N

    Butenafine_[INN] RX_link

    http://www.rxlist.com/cgi/generic2/butenafine.htm

    Butenafine_[INN] fda sheet

    Butenafine_[INN] FDA

    Butenafine_[INN] msds (material safety sheet)

    Butenafine_[INN] Synthesis Reference

    No information avaliable

    Butenafine_[INN] Molecular Weight

    317.467 g/mol

    Butenafine_[INN] Melting Point

    No information avaliable

    Butenafine_[INN] H2O Solubility

    Slightly soluble (HCl salt)

    Butenafine_[INN] State

    Solid

    Butenafine_[INN] LogP

    7.12

    Butenafine_[INN] Dosage Forms

    Cream (10 mg drug per gram of cream)

    Butenafine_[INN] Indication

    For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.

    Butenafine_[INN] Pharmacology

    Butenafine is an antifungal agent that acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. It is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.

    Butenafine_[INN] Absorption

    The total amount absorbed through the skin into the systemic circulation has not been quantified.

    Butenafine_[INN] Toxicity

    No information avaliable

    Butenafine_[INN] Patient Information

    Butenafine_[INN] Organisms Affected

    Fungi