Butenafinum_[INN-Latin]

Category

Butenafinum_[INN-Latin]




Useful info

Butenafinum_[INN-Latin] Brand names, Butenafinum_[INN-Latin] Analogs

Butenafinum_[INN-Latin] Brand Names Mixture

  • No information avaliable

    • Butenafinum_[INN-Latin] Chemical_Formula

    C23H27N

    Butenafinum_[INN-Latin] RX_link

    http://www.rxlist.com/cgi/generic2/butenafine.htm

    Butenafinum_[INN-Latin] fda sheet

    Butenafinum_[INN-Latin] FDA

    Butenafinum_[INN-Latin] msds (material safety sheet)

    Butenafinum_[INN-Latin] Synthesis Reference

    No information avaliable

    Butenafinum_[INN-Latin] Molecular Weight

    317.467 g/mol

    Butenafinum_[INN-Latin] Melting Point

    No information avaliable

    Butenafinum_[INN-Latin] H2O Solubility

    Slightly soluble (HCl salt)

    Butenafinum_[INN-Latin] State

    Solid

    Butenafinum_[INN-Latin] LogP

    7.12

    Butenafinum_[INN-Latin] Dosage Forms

    Cream (10 mg drug per gram of cream)

    Butenafinum_[INN-Latin] Indication

    For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.

    Butenafinum_[INN-Latin] Pharmacology

    Butenafine is an antifungal agent that acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. It is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.

    Butenafinum_[INN-Latin] Absorption

    The total amount absorbed through the skin into the systemic circulation has not been quantified.

    Butenafinum_[INN-Latin] Toxicity

    No information avaliable

    Butenafinum_[INN-Latin] Patient Information

    Butenafinum_[INN-Latin] Organisms Affected

    Fungi