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Fluracilum Brand names, Fluracilum Analogs

Fluracilum Brand Names Mixture

  • No information avaliable

Fluracilum Chemical_Formula


Fluracilum RX_link


Fluracilum fda sheet

Fluracilum FDA

Fluracilum msds (material safety sheet)

Fluracilum MSDS

Fluracilum Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

Fluracilum Molecular Weight

130.077 g/mol

Fluracilum Melting Point


Fluracilum H2O Solubility

< 0.1 g/100 mL at 19 °C

Fluracilum State


Fluracilum LogP


Fluracilum Dosage Forms

Topical preparations; Solution for injection

Fluracilum Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Fluracilum Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Fluracilum Absorption


Fluracilum side effects and Toxicity

LD50=230mg/kg (orally in mice)

Fluracilum Patient Information

Fluracilum Organisms Affected

Humans and other mammals