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Ulup
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Ulup Brand names, Ulup Analogs

Ulup Brand Names Mixture

  • No information avaliable

Ulup Chemical_Formula

C4H3FN2O2

Ulup RX_link

http://www.rxlist.com/cgi/generic3/carac.htm

Ulup fda sheet

Ulup FDA

Ulup msds (material safety sheet)

Ulup MSDS

Ulup Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

Ulup Molecular Weight

130.077 g/mol

Ulup Melting Point

280-282oC

Ulup H2O Solubility

< 0.1 g/100 mL at 19 °C

Ulup State

Solid

Ulup LogP

-0.77

Ulup Dosage Forms

Topical preparations; Solution for injection

Ulup Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Ulup Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Ulup Absorption

28-100%

Ulup side effects and Toxicity

LD50=230mg/kg (orally in mice)

Ulup Patient Information

Ulup Organisms Affected

Humans and other mammals