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Efudix Brand names, Efudix Analogs

Efudix Brand Names Mixture

  • No information avaliable

Efudix Chemical_Formula


Efudix RX_link


Efudix fda sheet

Efudix FDA

Efudix msds (material safety sheet)

Efudix MSDS

Efudix Synthesis Reference

Heidelberger et al., U.S. Pat 2802005(1956)

Efudix Molecular Weight

130.077 g/mol

Efudix Melting Point


Efudix H2O Solubility

< 0.1 g/100 mL at 19 °C

Efudix State


Efudix LogP


Efudix Dosage Forms

Topical preparations; Solution for injection

Efudix Indication

For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Efudix Pharmacology

Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Efudix Absorption


Efudix side effects and Toxicity

LD50=230mg/kg (orally in mice)

Efudix Patient Information

Efudix Organisms Affected

Humans and other mammals