5_Fluorouracil
Category
5_Fluorouracil Brand names, 5_Fluorouracil Analogs
5_Fluorouracil Brand Names Mixture
No information avaliable
5_Fluorouracil Chemical_Formula
C4H3FN2O2
5_Fluorouracil RX_link
http://www.rxlist.com/cgi/generic3/carac.htm
5_Fluorouracil fda sheet
5_Fluorouracil msds (material safety sheet)
5_Fluorouracil Synthesis Reference
Heidelberger et al., U.S. Pat 2802005(1956)
5_Fluorouracil Molecular Weight
130.077 g/mol
5_Fluorouracil Melting Point
280-282oC
5_Fluorouracil H2O Solubility
< 0.1 g/100 mL at 19 °C
5_Fluorouracil State
Solid
5_Fluorouracil LogP
-0.77
5_Fluorouracil Dosage Forms
Topical preparations; Solution for injection
5_Fluorouracil Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.
5_Fluorouracil Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.
5_Fluorouracil Absorption
28-100%
5_Fluorouracil Toxicity
LD50=230mg/kg (orally in mice)
5_Fluorouracil Patient Information
5_Fluorouracil Organisms Affected
Humans and other mammals
