Biperidene_Hydrochloride

Category

Biperidene_Hydrochloride




Useful info

Biperidene_Hydrochloride Brand names, Biperidene_Hydrochloride Analogs

Biperidene_Hydrochloride Brand Names Mixture

  • No information avaliable

    • Biperidene_Hydrochloride Chemical_Formula

    C21H29NO

    Biperidene_Hydrochloride RX_link

    http://www.rxlist.com/cgi/generic2/biperiden.htm

    Biperidene_Hydrochloride fda sheet

    Biperidene_Hydrochloride msds (material safety sheet)

    Biperidene_Hydrochloride Synthesis Reference

    No information avaliable

    Biperidene_Hydrochloride Molecular Weight

    311.461 g/mol

    Biperidene_Hydrochloride Melting Point

    114 oC

    Biperidene_Hydrochloride H2O Solubility

    25.1 mg/L

    Biperidene_Hydrochloride State

    Solid

    Biperidene_Hydrochloride LogP

    3.85

    Biperidene_Hydrochloride Dosage Forms

    Tablet

    Biperidene_Hydrochloride Indication

    For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.

    Biperidene_Hydrochloride Pharmacology

    Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden, these drug-induced disturbances are rapidly brought under control.

    Biperidene_Hydrochloride Absorption

    87% bioavailability

    Biperidene_Hydrochloride Toxicity

    LD50=760 mg/kg (Orally in rats). Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.

    Biperidene_Hydrochloride Patient Information

    No information avaliable

    Biperidene_Hydrochloride Organisms Affected

    Humans and other mammals