Beperiden
Category
Beperiden Brand names, Beperiden Analogs
Beperiden Brand Names Mixture
Beperiden Chemical_Formula
C21H29NO
Beperiden RX_link
http://www.rxlist.com/cgi/generic2/biperiden.htm
Beperiden fda sheet
Beperiden msds (material safety sheet)
Beperiden Synthesis Reference
No information avaliable
Beperiden Molecular Weight
311.461 g/mol
Beperiden Melting Point
114 oC
Beperiden H2O Solubility
25.1 mg/L
Beperiden State
Solid
Beperiden LogP
3.85
Beperiden Dosage Forms
Tablet
Beperiden Indication
For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.
Beperiden Pharmacology
Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden, these drug-induced disturbances are rapidly brought under control.
Beperiden Absorption
87% bioavailability
Beperiden side effects and Toxicity
LD50=760 mg/kg (Orally in rats). Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Beperiden Patient Information
No information avaliable
Beperiden Organisms Affected
Humans and other mammals
