Akinophyl
Category
Akinophyl Brand names, Akinophyl Analogs
Akinophyl Brand Names Mixture
No information avaliable
Akinophyl Chemical_Formula
C21H29NO
Akinophyl RX_link
http://www.rxlist.com/cgi/generic2/biperiden.htm
Akinophyl fda sheet
Akinophyl msds (material safety sheet)
Akinophyl Synthesis Reference
No information avaliable
Akinophyl Molecular Weight
311.461 g/mol
Akinophyl Melting Point
114 oC
Akinophyl H2O Solubility
25.1 mg/L
Akinophyl State
Solid
Akinophyl LogP
3.85
Akinophyl Dosage Forms
Tablet
Akinophyl Indication
For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.
Akinophyl Pharmacology
Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden, these drug-induced disturbances are rapidly brought under control.
Akinophyl Absorption
87% bioavailability
Akinophyl Toxicity
LD50=760 mg/kg (Orally in rats). Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Akinophyl Patient Information
No information avaliable
Akinophyl Organisms Affected
Humans and other mammals
