Akineton
Category
Akineton Brand names, Akineton Analogs
Akineton Brand Names Mixture
No information avaliable
Akineton Chemical_Formula
C21H29NO
Akineton RX_link
http://www.rxlist.com/cgi/generic2/biperiden.htm
Akineton fda sheet
Akineton msds (material safety sheet)
Akineton Synthesis Reference
No information avaliable
Akineton Molecular Weight
311.461 g/mol
Akineton Melting Point
114 oC
Akineton H2O Solubility
25.1 mg/L
Akineton State
Solid
Akineton LogP
3.85
Akineton Dosage Forms
Tablet
Akineton Indication
For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.
Akineton Pharmacology
Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden, these drug-induced disturbances are rapidly brought under control.
Akineton Absorption
87% bioavailability
Akineton Toxicity
LD50=760 mg/kg (Orally in rats). Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Akineton Patient Information
No information avaliable
Akineton Organisms Affected
Humans and other mammals
