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Aldomin Brand names, Aldomin Analogs

Aldomin Brand Names Mixture

  • No information avaliable

Aldomin Chemical_Formula

C56H71N9O23S

Aldomin RX_link

http://www.rxlist.com/cgi/generic4/mycamine.htm

Aldomin fda sheet

Aldomin FDA

Aldomin msds (material safety sheet)

Aldomin MSDS

Aldomin Synthesis Reference

No information avaliable

Aldomin Molecular Weight

1270.28 g/mol

Aldomin Melting Point

No information avaliable

Aldomin H2O Solubility

Freely soluble as sodium salt (> 200mg/mL)

Aldomin State

Solid

Aldomin LogP

No information avaliable

Aldomin Dosage Forms

Powder for solution (for injection)

Aldomin Indication

For use in the treatment of patients with esophageal candidiasis and prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation.

Aldomin Pharmacology

Formerly known as FK463, micafungin is a novel antifungal agent. It is a glucan synthesis inhibitor of the echinocandin structural class. The U.S. Food and Drug Administration approved micafungin in March 2005. Micafungin inhibits an enzyme essential for fungal cell-wall synthesis and is fungicidal (lethal) for Candida. Micafungin can be used concomitantly with a variety of other drugs, including the HIV protease inhibitor ritonavir and the transplant medications cyclosporine and tacrolimus.

Aldomin Absorption

No information avaliable

Aldomin side effects and Toxicity

Intravenous LD50 in rats is 125mg/kg. In dogs it is >200mg/kg. No cases of overdosage have been reported. Repeated daily doses up to 8 mg/kg (maximum total dose of 896 mg) in adult patients have been administered in clinical trials with no reported dose-limiting toxicity. The minimum lethal dose is 125 mg/kg in rats, equivalent to 8.1 times the recommended human clinical dose for esophageal candidiasis based on body surface area comparisons.

Aldomin Patient Information

No information avaliable

Aldomin Organisms Affected

Aspergillis, Candida and other fungi