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Alcophobin Brand names, Alcophobin Analogs

Alcophobin Brand Names Mixture

  • No information avaliable

Alcophobin Chemical_Formula

C10H20N2S4

Alcophobin RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Alcophobin fda sheet

Alcophobin msds (material safety sheet)

Alcophobin MSDS

Alcophobin Synthesis Reference

No information avaliable

Alcophobin Molecular Weight

296.543 g/mol

Alcophobin Melting Point

71.5 oC

Alcophobin H2O Solubility

4.09 mg/L

Alcophobin State

Solid

Alcophobin LogP

4.422

Alcophobin Dosage Forms

Tablet

Alcophobin Indication

For the treatment and management of chronic alcoholism

Alcophobin Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Alcophobin Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Alcophobin side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Alcophobin Patient Information

No information avaliable

Alcophobin Organisms Affected

Humans and other mammals