Tetraethylthiram Disulphide en es it fr

Tetraethylthiram Disulphide Brand names, Tetraethylthiram Disulphide Analogs

Tetraethylthiram Disulphide Brand Names Mixture

  • No information avaliable

Tetraethylthiram Disulphide Chemical_Formula

C10H20N2S4

Tetraethylthiram Disulphide RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Tetraethylthiram Disulphide fda sheet

Tetraethylthiram Disulphide msds (material safety sheet)

Tetraethylthiram_Disulphide MSDS

Tetraethylthiram Disulphide Synthesis Reference

No information avaliable

Tetraethylthiram Disulphide Molecular Weight

296.543 g/mol

Tetraethylthiram Disulphide Melting Point

71.5 oC

Tetraethylthiram Disulphide H2O Solubility

4.09 mg/L

Tetraethylthiram Disulphide State

Solid

Tetraethylthiram Disulphide LogP

4.422

Tetraethylthiram Disulphide Dosage Forms

Tablet

Tetraethylthiram Disulphide Indication

For the treatment and management of chronic alcoholism

Tetraethylthiram Disulphide Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Tetraethylthiram Disulphide Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Tetraethylthiram Disulphide side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Tetraethylthiram Disulphide Patient Information

No information avaliable

Tetraethylthiram Disulphide Organisms Affected

Humans and other mammals