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Thioscabin Brand names, Thioscabin Analogs

Thioscabin Brand Names Mixture

  • No information avaliable

Thioscabin Chemical_Formula

C10H20N2S4

Thioscabin RX_link

http://www.rxlist.com/cgi/generic/disulfiram.htm

Thioscabin fda sheet

Thioscabin msds (material safety sheet)

Thioscabin MSDS

Thioscabin Synthesis Reference

No information avaliable

Thioscabin Molecular Weight

296.543 g/mol

Thioscabin Melting Point

71.5 oC

Thioscabin H2O Solubility

4.09 mg/L

Thioscabin State

Solid

Thioscabin LogP

4.422

Thioscabin Dosage Forms

Tablet

Thioscabin Indication

For the treatment and management of chronic alcoholism

Thioscabin Pharmacology

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body. Prolonged administration of disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

Thioscabin Absorption

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Thioscabin side effects and Toxicity

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Thioscabin Patient Information

No information avaliable

Thioscabin Organisms Affected

Humans and other mammals