tPA
tPA Brand names, tPA Analogs
tPA Brand Names Mixture
- No information avaliable
tPA Chemical_Formula
C1736H2671N499O522S22
tPA RX_link
http://www.rxlist.com/cgi/generic2/reteplase.htm
tPA fda sheet
tPA msds (material safety sheet)
tPA Synthesis Reference
No information avaliable
tPA Molecular Weight
39589.6
tPA Melting Point
60 oC (Novokhatny, V.V. et al., J. Biol. Chem. 266:12994-123002 (1991))
tPA H2O Solubility
No information avaliable
tPA State
Liquid
tPA LogP
-0.435
tPA Dosage Forms
Solution (IV injection); Powder for solution
tPA Indication
For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction
tPA Pharmacology
Retavase cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.
tPA Absorption
No information avaliable
tPA side effects and Toxicity
No information avaliable
tPA Patient Information
No information avaliable
tPA Organisms Affected
Humans and other mammals
