Oxamide
Categoria
Oxamide Marchi, Oxamide Analoghi
- ACT
- ACT D
- ACTINOMYCIN D
- ACTO-D
- AD
- Actactinomycin a Iv
- Actinomycin 11 Cosmegen
- Actinomycin 7
- Actinomycin Aiv
- Actinomycin C1
- Actinomycin I
- Actinomycin I1
- Actinomycin Iv
- Actinomycin X 1
- Actinomycindioic D Acid, Dilactone
- Antibiotic From Streptomyces Parvullus
- Chounghwamycin B
- Cosmegen
- Dactinomicina [Inn-Spanish]
- Dactinomycin D
- Dactinomycin [Usan:Ban]
- Dactinomycine [Inn-French]
- Dactinomycinum [Inn-Latin]
- Dilactone Actinomycin D Acid
- Dilactone Actinomycindioic D Acid
- Hbf 386 Meractinomycin
- Lyovac Cosmegen
- Meractinomycin
- Oncostatin K
- Oxamide
Oxamide Marchi miscela
Oxamide Formula chimica
C62H86N12O16
Oxamide RX link
http://www.rxlist.com/cgi/generic2/dactinomycin.htm
Oxamide FDA foglio
Oxamide DMS (foglio di materiale di sicurezza)
Oxamide Sintesi di riferimento
Brockmann et al; Chem.Ber;. 93; 2971,2975 (1960)
Oxamide Peso molecolare
1255.42 g/mol
Oxamide Temperatura di fusione
241.5 - 243 oC
Oxamide H2O Solubilita
Solubile a 10 ° C
Oxamide Stato
solid
Oxamide LogP
0.517
Oxamide Forme di dosaggio
Soluzione iniettabile e parenterale
Oxamide Indicazione
Per il trattamento del tumore di Wilms ', l'infanzia rabdomiosarcoma, il sarcoma di Ewing e metastatica, il tumore testicolare seminomatoso come parte di una chemioterapia di combinazione e / o multi-modalità regime di trattamento
Oxamide Farmacologia
In generale, il actinomycins esercitano un effetto inibitorio sui batteri gram-positivi e gram-negativi e su alcuni funghi. Tuttavia, le proprietà tossiche del actinomycins (compresi dactinomicina) in relazione all'attività antibatterica sono tali da precluderne l'uso di antibiotici nel trattamento delle malattie infettive. Poiché il actinomycins sono citotossici, hanno un effetto antineoplastico che ha stata dimostrata in animali da esperimento con diversi tipi di impianto del tumore. Questa azione citotossica è la base per il loro uso nel trattamento di alcuni tipi di cancro. Dactinomicina si crede produrre i suoi effetti citotossici di legame del DNA e inibendo la sintesi di RNA.
Oxamide Assorbimento
scarsamente assorbito dal tratto gastrointestinale
Oxamide Tossicita
epatotossicità
Oxamide Informazioni paziente
Dactinomycin is a type of antibiotic that is only used in cancer
chemotherapy. It slows or stops the growth of cancer cells in your
body. The length of treatment depends on the types of drugs you are
taking, how well your body responds to them, and the type of cancer
you have. tell your doctor and pharmacist if you are allergic to
dactinomycin or any other drugs. tell your doctor and pharmacist
what prescription and nonprescription medications you are taking,
especially aspirin and vitamins. tell your doctor if you have or
have ever had liver disease, ulcers, or gastrointestinal disease.
you should know that dactinomycin may interfere with the normal
menstrual cycle (period) in women and may stop sperm production
in men. However, you should not assume that you cannot get pregnant
or that you cannot get someone else pregnant. Women who are pregnant
or breast-feeding should tell their doctors before they begin taking
this drug. You should not plan to have children while receiving
chemotherapy or for a while after treatments. (Talk to your doctor
for further details.) Use a reliable method of birth control to
prevent pregnancy. Dactinomycin may harm the fetus. do not have any
vaccinations (e.g., measles or flu shots) without talking to your
doctor.
chemotherapy. It slows or stops the growth of cancer cells in your
body. The length of treatment depends on the types of drugs you are
taking, how well your body responds to them, and the type of cancer
you have. tell your doctor and pharmacist if you are allergic to
dactinomycin or any other drugs. tell your doctor and pharmacist
what prescription and nonprescription medications you are taking,
especially aspirin and vitamins. tell your doctor if you have or
have ever had liver disease, ulcers, or gastrointestinal disease.
you should know that dactinomycin may interfere with the normal
menstrual cycle (period) in women and may stop sperm production
in men. However, you should not assume that you cannot get pregnant
or that you cannot get someone else pregnant. Women who are pregnant
or breast-feeding should tell their doctors before they begin taking
this drug. You should not plan to have children while receiving
chemotherapy or for a while after treatments. (Talk to your doctor
for further details.) Use a reliable method of birth control to
prevent pregnancy. Dactinomycin may harm the fetus. do not have any
vaccinations (e.g., measles or flu shots) without talking to your
doctor.
Oxamide Atto interessato organismi
Gli esseri umani e altri mammiferi
