Dactinomycin D

• Antibiotics
• Anti-bacterial Agents
• Antineoplastic Agents
• ATC:L01DA01

• ACT
• ACT D
• ACTINOMYCIN D
• ACTO-D
• AD
• Actactinomycin a Iv
• Actinomycin 11 Cosmegen
• Actinomycin 7
• Actinomycin Aiv
• Actinomycin C1
• Actinomycin I
• Actinomycin I1
• Actinomycin Iv
• Actinomycin X 1
• Actinomycindioic D Acid, Dilactone
• Antibiotic From Streptomyces Parvullus
• Chounghwamycin B
• Cosmegen
• Dactinomicina [Inn-Spanish]
• Dactinomycin D
• Dactinomycin [Usan:Ban]
• Dactinomycine [Inn-French]
• Dactinomycinum [Inn-Latin]
• Dilactone Actinomycin D Acid
• Dilactone Actinomycindioic D Acid
• Hbf 386 Meractinomycin
• Lyovac Cosmegen
• Meractinomycin
• Oncostatin K
• Oxamide

• No information avaliable

C₆₂H₈₆N₁₂O₁₆

http://www.rxlist.com/cgi/generic2/dactinomycin.htm

Brockmann et al; Chem.Ber.; 93; 2971,2975(1960)

1255.42 g/mol

241.5 - 243 ^oC

Soluble at 10°C

solid

0.517

Injectable and parenteral solution

For the treatment of Wilms' tumor, childhood rhabdomyosarcoma, Ewing's sarcoma and metastatic, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen

Generally, the actinomycins exert an inhibitory effect on gram-positive and gram-negative bacteria and on some fungi. However, the toxic properties of the actinomycins (including dactinomycin) in relation to antibacterial activity are such as to preclude their use as antibiotics in the treatment of infectious diseases. Because the actinomycins are cytotoxic, they have an antineoplastic effect which has been demonstrated in experimental animals with various types of tumor implant. This cytotoxic action is the basis for their use in the treatment of certain types of cancer. Dactinomycin is believed to produce its cytotoxic effects by binding DNA and inhibiting RNA synthesis.

poorly absorbed from gastrointestinal tract

hepatoxicity

Dactinomycin is a type of antibiotic that is only used in cancer
chemotherapy. It slows or stops the growth of cancer cells in your
body. The length of treatment depends on the types of drugs you are
taking, how well your body responds to them, and the type of cancer
you have. tell your doctor and pharmacist if you are allergic to
dactinomycin or any other drugs. tell your doctor and pharmacist
what prescription and nonprescription medications you are taking,
especially aspirin and vitamins. tell your doctor if you have or
have ever had liver disease, ulcers, or gastrointestinal disease.
you should know that dactinomycin may interfere with the normal
menstrual cycle (period) in women and may stop sperm production
in men. However, you should not assume that you cannot get pregnant
or that you cannot get someone else pregnant. Women who are pregnant
or breast-feeding should tell their doctors before they begin taking
this drug. You should not plan to have children while receiving
chemotherapy or for a while after treatments. (Talk to your doctor
for further details.) Use a reliable method of birth control to
prevent pregnancy. Dactinomycin may harm the fetus. do not have any
vaccinations (e.g., measles or flu shots) without talking to your
doctor.

Humans and other mammals