Isosorbide Dinitrate
Categoria
Isosorbide Dinitrate Marchi, Isosorbide Dinitrate Analoghi
- Cardio 10
- Cardis
- Carvanil
- Carvasin
- Cedocard
- Claodical
- Cornilat
- Coronex
- Corosorbide
- Dianhydrosorbitol 2,5-dinitrate
- Difutrat
- Dilatrate
- Dilatrate-SR
- Dinitrosorbide
- Emoper
- Flindix
- Harrical
- IBD 20
- ISD
- ISDN
- Ismotic
- Iso-Bid
- Isochron
- Isoket
- Isorbid;
- Isordil
- Isordil Tembids
- Isosorbide dinitrate(USAN)
- Isostat
- Isotrate
- Korodil
- Lomilan
- Maycor
- Myorexon
- Nitrosorbid
- Nitrosorbide
- Nitrosorbon
- Nosim
- Resoidan
- Rifloc Retard
- Rigedal
- Sorbangil
- Sorbide T.D.
- Sorbide nitrate
- Sorbide, dinitrate
- Sorbidilat
- Sorbidnitrate
- Sorbislo
- Sorbitrate
- Sorbonit
- Sorquad
- Tinidil
- Titradose
- Vascardin
- Vasodilat
- Vasorbate
- Xanyl
Isosorbide Dinitrate Marchi miscela
Isosorbide Dinitrate Formula chimica
C6H8N2O8
Isosorbide Dinitrate RX link
http://www.rxlist.com/cgi/generic2/isodinit.htm
Isosorbide Dinitrate FDA foglio
Isosorbide Dinitrate DMS (foglio di materiale di sicurezza)
Isosorbide Dinitrate Sintesi di riferimento
Goldberg, Acta Physiol. Scand.15, 173 (1948)
Isosorbide Dinitrate Peso molecolare
236.136 g/mol
Isosorbide Dinitrate Temperatura di fusione
70 oC
Isosorbide Dinitrate H2O Solubilita
1,089 mg / ml
Isosorbide Dinitrate Stato
Solid
Isosorbide Dinitrate LogP
-0.53
Isosorbide Dinitrate Forme di dosaggio
Orale
Isosorbide Dinitrate Indicazione
Per la prevenzione di angina pectoris a causa di malattia coronarica.
Isosorbide Dinitrate Farmacologia
Dinitrato è un moderato a lunga durata d'azione nitrati organici orale usato per il sollievo e la gestione profilattico di angina pectoris. Si rilassa la muscolatura liscia vascolare e conseguente dilatazione delle arterie periferiche e delle vene, soprattutto il secondo. Dilatazione delle vene promuove la messa in comune periferico di sangue e diminuisce il ritorno venoso al cuore, riducendo così ventricolare sinistra telediastolica pressione e pressione polmonare capillare (precarico). Rilassamento arteriolare riduce le resistenze vascolari sistemiche, la pressione arteriosa sistolica e pressione arteriosa media.
Isosorbide Dinitrate Assorbimento
L'assorbimento di dinitrato dopo somministrazione orale è quasi completa, ma la biodisponibilità è molto variabile (10% al 90%), con ampio metabolismo di primo passaggio nel fegato. La biodisponibilità media di dinitrato è di circa il 25%.
Isosorbide Dinitrate Tossicita
Sintomi di sovradosaggio includono riduzione della gittata cardiaca e ipotensione.
Isosorbide Dinitrate Informazioni paziente
PATIENT INFORMATION
Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.
Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol
Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.
Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol
Isosorbide Dinitrate Atto interessato organismi
Gli esseri umani e altri mammiferi
