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Marchi,
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Analoghi
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Marchi miscela
AK Vernacon Oph Soln (Pheniramine Maleate + Phenylephrine Hydrochloride) Biohisdex DM Decongestant (Dextromethorphan Hydrobromide + Diphenylpyraline Hydrochloride + Phenylephrine Hydrochloride) Biohisdine DM Decongestant (Dextromethorphan Hydrobromide + Diphenylpyraline Hydrochloride + Phenylephrine Hydrochloride) Chemhisdex DM Decongestant (Dextromethorphan Hydrobromide + Diphenylpyraline Hydrochloride + Phenylephrine Hydrochloride) Chemhisdine DM Decongestant (Dextromethorphan Hydrobromide + Diphenylpyraline Hydrochloride + Phenylephrine Hydrochloride) Citron Chaud Cumberland Pws (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Citron Chaud DM Cumberland Pws (Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Codalin (Codeine Phosphate + Diphenylpyraline Hydrochloride + Phenylephrine Hydrochloride) Cold & Allergy (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Cold & Allergy Relief - Liq (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Cough, Cold & Allergy Relief (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Decongestant Antihistaminic Syrup (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetane Expectorant Liq (Brompheniramine Maleate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetane Expectorant-C Syr (Brompheniramine Maleate + Codeine Phosphate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetane Expectorant-DC Syr (Brompheniramine Maleate + Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp (Brompheniramine Maleate + Phenylephrine Hydrochloride) Dimetapp Cold & Sinus (Acetaminophen + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp DM Elixir (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp DM Tab (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Extentabs (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Extra Strength (Brompheniramine Maleate + Phenylephrine Hydrochloride) Dimetapp Oral Infant Cold Drops (Brompheniramine Maleate + Phenylephrine Hydrochloride) Dimetapp Oral Infant Drops (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Tab (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp-C Syr (Brompheniramine Maleate + Codeine Phosphate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Hemorrhoidal Ointment (Mineral Oil + Petrolatum + Phenylephrine Hydrochloride + Shark Liver Oil) Hot Lemon for Colds Powder (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Hot Lemon Relief DM Adult (Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylephrine Hydrochloride) Hot Lemon Relief for Cold Symptoms Ext Str (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Hot Lemon Relief for Cold Symptoms Pws (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Hot Lemon Relief Pws (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Lemon Relief for Adults (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride) Lemon Time (Acetaminophen + Phenylephrine Hydrochloride + Pyrilamine Maleate + Vitamin C) Neo Citran a Powder (Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Neo Citran Extra Strength (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride) Neo Citran Nutrasweet (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride) Neo Citran Powder (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Neo Synephrine Nasal Spray (Phenylephrine Hydrochloride + Thenyldiamine Hcl.) Neo-Synephrine Nasal Spray (Phenylephrine Hydrochloride + Thenyldiamine Hcl.) Nezger Tab (Acetylsalicylic Acid + Diphenylpyraline Hydrochloride + Guaifenesin + Phenylephrine Hydrochloride) Novahistex C (Codeine Phosphate + Phenylephrine Hydrochloride) Novahistex Dh Expectorant (Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride) Occu-Cal Drops (Boric Acid + Phenylephrine Hydrochloride + Sodium Borate) Occu-Cal Lotion (Boric Acid + Phenylephrine Hydrochloride + Sodium Borate) Pharmetapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Phenergan VC Expectorant Syr (Phenylephrine Hydrochloride + Potassium Guaiacol Sulphonate + Promethazine Hydrochloride) Phenergan VC Expectorant W Codeine Liq (Codeine Phosphate + Phenylephrine Hydrochloride + Potassium Guaiacol Sulphonate + Promethazine Hydrochloride) Soframycin Nasal Spray (Framycetin Sulfate + Gramicidin + Phenylephrine Hydrochloride) Tantapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Vasosulf Oph Soln (Phenylephrine Hydrochloride + Sulfacetamide Sodium)
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Formula chimica
C9H13NO2
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RX link
http://www.rxlist.com/cgi/generic3/phenyleph.htm
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FDA foglio
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DMS (foglio di materiale di sicurezza)
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Sintesi di riferimento
Sintesi di m-benzyloxybenzaldehyde: Bergmann, Sulzbacher, J. Org. Chem. 16, 84 (1951)
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Peso molecolare
167.205 g/mol
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Temperatura di fusione
140-145 oC
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H2O Solubilita
Facilmente solubile in acqua
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Stato
Solid
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LogP
0.63
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Forme di dosaggio
Soluzione oftalmica; soluzione nasale; Solution (IM, IV, IV e infusione sottocutanea), gel, crema, unguento; Supposta
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Indicazione
Per il trattamento dei disturbi oftalmici (iperemia della congiuntiva, sinechie posteriori, atopica acuta), congestione nasale, emorroidi, ipotensione, shock, ipotensione durante l'anestesia spinale, parossistica tachicardia sopraventricolare. Viene anche usato come ausilio nella diagnosi di soffi cardiaci e per il prolungamento di anestesia spinale
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Farmacologia
Fenilefrina è un potente vasocostrittore. È usato come agente midriatico, decongestionante nasale, e cardiotonico. Fenilefrina è un post-sinaptici alfa-stimolante, con scarso effetto sulla beta recettori del cuore. Somministrazione parenterale di fenilefrina provoca un aumento della pressione sistolica e diastolica, la gittata cardiaca è leggermente diminuito e la resistenza periferica è notevolmente aumentato, letti più vascolari sono ristretti; renale, splancnico, i flussi sanguigno cutaneo, e degli arti sono ridotti, ma il flusso sanguigno coronarico è aumentato. Vasi polmonari sono ristretti, e la pressione arteriosa polmonare è sollevata. Questo agonista del recettore alfa simpatico è utilizzato anche a livello locale perché la sua azione vasocostrittrice e midriatico.
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Assorbimento
Ridotta biodisponibilità (rispetto al pseudoefedrina) dopo somministrazione orale a causa della notevole metabolismo di primo passaggio.
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Tossicita
Nessuna informazione disponibile
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Informazioni paziente
No information avaliable
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Atto interessato organismi
Gli esseri umani e altri mammiferi
