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Nombres de marca,
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Analogos
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AK Vernacon Oph Soln (Pheniramine Maleate + Phenylephrine Hydrochloride) Biohisdex DM Decongestant (Dextromethorphan Hydrobromide + Diphenylpyraline Hydrochloride + Phenylephrine Hydrochloride) Biohisdine DM Decongestant (Dextromethorphan Hydrobromide + Diphenylpyraline Hydrochloride + Phenylephrine Hydrochloride) Chemhisdex DM Decongestant (Dextromethorphan Hydrobromide + Diphenylpyraline Hydrochloride + Phenylephrine Hydrochloride) Chemhisdine DM Decongestant (Dextromethorphan Hydrobromide + Diphenylpyraline Hydrochloride + Phenylephrine Hydrochloride) Citron Chaud Cumberland Pws (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Citron Chaud DM Cumberland Pws (Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Codalin (Codeine Phosphate + Diphenylpyraline Hydrochloride + Phenylephrine Hydrochloride) Cold & Allergy (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Cold & Allergy Relief - Liq (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Cough, Cold & Allergy Relief (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Decongestant Antihistaminic Syrup (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetane Expectorant Liq (Brompheniramine Maleate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetane Expectorant-C Syr (Brompheniramine Maleate + Codeine Phosphate + Guaifenesin + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetane Expectorant-DC Syr (Brompheniramine Maleate + Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp (Brompheniramine Maleate + Phenylephrine Hydrochloride) Dimetapp Cold & Sinus (Acetaminophen + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp DM Elixir (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp DM Tab (Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Extentabs (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Extra Strength (Brompheniramine Maleate + Phenylephrine Hydrochloride) Dimetapp Oral Infant Cold Drops (Brompheniramine Maleate + Phenylephrine Hydrochloride) Dimetapp Oral Infant Drops (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp Tab (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Dimetapp-C Syr (Brompheniramine Maleate + Codeine Phosphate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Hemorrhoidal Ointment (Mineral Oil + Petrolatum + Phenylephrine Hydrochloride + Shark Liver Oil) Hot Lemon for Colds Powder (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Hot Lemon Relief DM Adult (Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylephrine Hydrochloride) Hot Lemon Relief for Cold Symptoms Ext Str (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Hot Lemon Relief for Cold Symptoms Pws (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Hot Lemon Relief Pws (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Lemon Relief for Adults (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride) Lemon Time (Acetaminophen + Phenylephrine Hydrochloride + Pyrilamine Maleate + Vitamin C) Neo Citran a Powder (Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Neo Citran Extra Strength (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride) Neo Citran Nutrasweet (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride) Neo Citran Powder (Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C) Neo Synephrine Nasal Spray (Phenylephrine Hydrochloride + Thenyldiamine Hcl.) Neo-Synephrine Nasal Spray (Phenylephrine Hydrochloride + Thenyldiamine Hcl.) Nezger Tab (Acetylsalicylic Acid + Diphenylpyraline Hydrochloride + Guaifenesin + Phenylephrine Hydrochloride) Novahistex C (Codeine Phosphate + Phenylephrine Hydrochloride) Novahistex Dh Expectorant (Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride) Occu-Cal Drops (Boric Acid + Phenylephrine Hydrochloride + Sodium Borate) Occu-Cal Lotion (Boric Acid + Phenylephrine Hydrochloride + Sodium Borate) Pharmetapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Phenergan VC Expectorant Syr (Phenylephrine Hydrochloride + Potassium Guaiacol Sulphonate + Promethazine Hydrochloride) Phenergan VC Expectorant W Codeine Liq (Codeine Phosphate + Phenylephrine Hydrochloride + Potassium Guaiacol Sulphonate + Promethazine Hydrochloride) Soframycin Nasal Spray (Framycetin Sulfate + Gramicidin + Phenylephrine Hydrochloride) Tantapp Elixir (Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride) Vasosulf Oph Soln (Phenylephrine Hydrochloride + Sulfacetamide Sodium)
Doktors
Formula quimica
C9H13NO2
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RX enlace
http://www.rxlist.com/cgi/generic3/phenyleph.htm
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FDA hoja
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MSDS (hoja de seguridad de materiales)
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Sintesis de referencia
Síntesis de m-benzyloxybenzaldehyde: Bergmann, Sulzbacher, J. Org. Chem. 16, 84 (1951)
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Peso molecular
167.205 g/mol
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Punto de fusion
140-145 oC
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H2O Solubilidad
Muy soluble en agua
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Estado
Solid
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LogP
0.63
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Formas de dosificacion
Solución oftálmica, solución nasal, la solución (IM, IV, infusión IV y subcutánea), gel, crema, pomada, supositorios
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Indicacion
Para el tratamiento de los trastornos oftalmológicos (hiperemia de la conjuntiva, sinequias posteriores, aguda atópica), congestión nasal, hemorroides, hipotensión, shock, hipotensión durante la anestesia espinal paroxística taquicardia supraventricular. También se utiliza como una ayuda en el diagnóstico de soplos y para la prolongación de la anestesia espinal
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Farmacologia
La fenilefrina es un potente vasoconstrictor. Se usa como un agente midriático, descongestionantes nasales, y cardiotónico. La fenilefrina es un post-sináptica de receptores alfa-estimulante con poco efecto sobre la beta los receptores del corazón. La administración parenteral de fenilefrina provoca un aumento en la presión sistólica y diastólica, el gasto cardíaco se reduce ligeramente y la resistencia periférica aumenta considerablemente, mayoría de los lechos vasculares se contraen; renal, el flujo esplácnico, sanguíneo cutáneo, y de las extremidades se reducen, pero el flujo sanguíneo coronario aumenta. Los vasos pulmonares son la presión arterial restringido, y pulmonar se eleva. Este agonista de los receptores alfa simpático también se utiliza a nivel local debido a su acción vasoconstrictora y midriáticos.
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Absorcion
Reducción de la biodisponibilidad (en comparación con pseudoefedrina) tras la administración oral debido a la importante metabolismo de primer paso.
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Toxicidad
No hay información disponible
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Informacion de Pacientes
No information avaliable
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Organismos afectados
Humanos y otros mamíferos
