Angizem
Categoria
Angizem Marchi, Angizem Analoghi
- Acalix
- Adizem
- Altiazem
- Anginyl
- Angizem
- Anoheal
- Apo-Diltiaz
- Britiazim
- Bruzem
- Calcicard
- Cardizem
- Cardizem CD
- Cardizem SR
- Cardizen LA
- Cartia XT
- Citizem
- Cormax
- Deltazen
- Dilacor
- Dilacor-XR
- Diladel
- Dilcontin
- Dilpral
- Dilrene
- Dilt-cd
- Dilta-Hexal
- Diltia
- Dilticard
- Dilzem
- Dilzen
- Endrydil
- Herbesser
- Incoril AP
- Masdil
- Novo-Diltazem
- Nu-Diltiaz
- Syn-Diltiazem
- Tiazac Tildiem
- d-cis-Diltiazem
Angizem Marchi miscela
Angizem Formula chimica
C22H26N2O4S
Angizem RX link
http://www.rxlist.com/cgi/generic/diltiaz.htm
Angizem FDA foglio
Angizem DMS (foglio di materiale di sicurezza)
Angizem Sintesi di riferimento
Kugita H. et al. US Pat. 3,562,257 (1971)
Angizem Peso molecolare
414.519 g/mol
Angizem Temperatura di fusione
231oC
Angizem H2O Solubilita
465 mg / L
Angizem Stato
Solid
Angizem LogP
3.141
Angizem Forme di dosaggio
Soluzione
Angizem Indicazione
Per il trattamento dell'ipertensione
Angizem Farmacologia
Diltiazem, un benzothiazepine calcio-antagonista, è usato da solo o con un ACE-inibitore, per trattare l'ipertensione, angina pectoris cronica stabile e angina variante di Prinzmetal. Diltiazem è simile ad altri vasodilatatori periferici. Diltiazem inibisce l'afflusso di extra calcio attraverso le membrane cellulari del muscolo miocardico e liscia vascolare delle cellule eventualmente da deformare la canale, inibendo ionico gating meccanismi di controllo e / o interferendo con il rilascio di calcio dal reticolo sarcoplasmatico. La diminuzione del calcio intracellulare inibisce i processi contrattili delle cellule muscolari lisce del miocardio, provocando la dilatazione delle arterie coronariche e sistemica, una maggiore apporto di ossigeno al tessuto miocardico, diminuzione della resistenza periferica totale, riduzione sistemica pressione arteriosa, e diminuito post-carico.
Angizem Assorbimento
Diltiazem è ben assorbito dal tratto gastrointestinale, ma subisce sostanziali epatico effetto di primo passaggio.
Angizem Tossicita
LD50 = 740mg/kg (per via orale nei topi)
Angizem Informazioni paziente
PATIENT INFORMATION
Take this medicine exactly as directed even if you feel well and do not notice any signs of chest pain.
Do not take more of this medicine and do not take it more often than your doctor ordered.
Do not miss any doses.
Diltiazem is a calcium channel blocking agents. For the calcium channel blocking agents, the following should be considered:
-Tell your doctor if you have ever had any unusual or allergic reaction to amlodipine, bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, or verapamil. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
-Calcium channel blocking agents have not been studied in pregnant women. However, studies in animals have shown that large doses of calcium channel blocking agents cause birth defects, prolonged pregnancy, poor bone development in the offspring, and stillbirth.
-Although bepridil, diltiazem, nifedipine, verapamil, and possibly other calcium channel blocking agents, pass into breast milk, they have not been reported to cause problems in nursing babies.
-Although there is no specific information comparing use of this medicine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.
-Elderly people may be especially sensitive to the effects of calcium channel blocking agents. This may increase the chance of side effects during treatment. A lower starting dose may be required.
-The presence of other medical problems may affect the use of the calcium channel blocking agents. Make sure you tell your doctor if you have any other medical problems, especially
Follow Rxlist link and drugs.com link and other links for detailed information.
Take this medicine exactly as directed even if you feel well and do not notice any signs of chest pain.
Do not take more of this medicine and do not take it more often than your doctor ordered.
Do not miss any doses.
Diltiazem is a calcium channel blocking agents. For the calcium channel blocking agents, the following should be considered:
-Tell your doctor if you have ever had any unusual or allergic reaction to amlodipine, bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, or verapamil. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
-Calcium channel blocking agents have not been studied in pregnant women. However, studies in animals have shown that large doses of calcium channel blocking agents cause birth defects, prolonged pregnancy, poor bone development in the offspring, and stillbirth.
-Although bepridil, diltiazem, nifedipine, verapamil, and possibly other calcium channel blocking agents, pass into breast milk, they have not been reported to cause problems in nursing babies.
-Although there is no specific information comparing use of this medicine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.
-Elderly people may be especially sensitive to the effects of calcium channel blocking agents. This may increase the chance of side effects during treatment. A lower starting dose may be required.
-The presence of other medical problems may affect the use of the calcium channel blocking agents. Make sure you tell your doctor if you have any other medical problems, especially
Follow Rxlist link and drugs.com link and other links for detailed information.
Angizem Atto interessato organismi
Gli esseri umani e altri mammiferi
