Novo-Diltazem

• Vasodilator Agents
• Cardiovascular Agents
• Antihypertensive Agents
• Calcium-channel blocking agents
• ATC:C08DB01

• Acalix
• Adizem
• Altiazem
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• Dilt-cd
• Dilta-Hexal
• Diltia
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• Dilzem
• Dilzen
• Endrydil
• Herbesser
• Incoril AP
• Masdil
• Novo-Diltazem
• Nu-Diltiaz
• Syn-Diltiazem
• Tiazac Tildiem
• d-cis-Diltiazem

No information avaliable

C₂₂H₂₆N₂O₄S

http://www.rxlist.com/cgi/generic/diltiaz.htm

Novo-Diltazem FDA

Novo-Diltazem MSDS

H. Kugita et al., US. 3,562,257 (1971)

414.519 g/mol

231^oC

465 mg / L

Solid

3.141

Solution

Pour le traitement de l'hypertension

Diltiazem, un benzothiazépine inhibiteur calcique, est utilisé seul ou avec une conversion de l'angiotensine inhibiteur de l'enzyme, pour traiter l'hypertension, angine de poitrine chronique stable, et l'angine de Prinzmetal variante. Diltiazem est similaire à d'autres vasodilatateurs périphériques. Diltiazem inhibe l'influx de calcium extracellulaire à travers le myocarde et lisse vasculaire membranes des cellules musculaires éventuellement par déformation de la canal, l'inhibition des mécanismes de déclenchement d'ions de contrôle, et / ou interférer avec la libération de calcium par le réticulum sarcoplasmique. La diminution du calcium intracellulaire inhibe les processus contractiles des cellules du muscle lisse du myocarde, la dilatation provoque des artères coronaires et systémiques, l'augmentation de l'apport d'oxygène vers les tissus du myocarde, une diminution de la résistance périphérique totale, une diminution systémique la pression artérielle, et une diminution de la postcharge.

Diltiazem est bien absorbé par le tractus gastro-intestinal, mais subit substantielle de premier passage hépatique effet.

DL50 = 740mg/kg (par voie orale chez la souris)

PATIENT INFORMATION

Take this medicine exactly as directed even if you feel well and do not notice any signs of chest pain.

Do not take more of this medicine and do not take it more often than your doctor ordered.

Do not miss any doses.

Diltiazem is a calcium channel blocking agents. For the calcium channel blocking agents, the following should be considered:

-Tell your doctor if you have ever had any unusual or allergic reaction to amlodipine, bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, or verapamil. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

-Calcium channel blocking agents have not been studied in pregnant women. However, studies in animals have shown that large doses of calcium channel blocking agents cause birth defects, prolonged pregnancy, poor bone development in the offspring, and stillbirth.

-Although bepridil, diltiazem, nifedipine, verapamil, and possibly other calcium channel blocking agents, pass into breast milk, they have not been reported to cause problems in nursing babies.

-Although there is no specific information comparing use of this medicine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.

-Elderly people may be especially sensitive to the effects of calcium channel blocking agents. This may increase the chance of side effects during treatment. A lower starting dose may be required.

-The presence of other medical problems may affect the use of the calcium channel blocking agents. Make sure you tell your doctor if you have any other medical problems, especially

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