ACTO-D
Categorie
ACTO-D Les marques, ACTO-D Analogs
- ACT
- ACT D
- ACTINOMYCIN D
- ACTO-D
- AD
- Actactinomycin a Iv
- Actinomycin 11 Cosmegen
- Actinomycin 7
- Actinomycin Aiv
- Actinomycin C1
- Actinomycin I
- Actinomycin I1
- Actinomycin Iv
- Actinomycin X 1
- Actinomycindioic D Acid, Dilactone
- Antibiotic From Streptomyces Parvullus
- Chounghwamycin B
- Cosmegen
- Dactinomicina [Inn-Spanish]
- Dactinomycin D
- Dactinomycin [Usan:Ban]
- Dactinomycine [Inn-French]
- Dactinomycinum [Inn-Latin]
- Dilactone Actinomycin D Acid
- Dilactone Actinomycindioic D Acid
- Hbf 386 Meractinomycin
- Lyovac Cosmegen
- Meractinomycin
- Oncostatin K
- Oxamide
ACTO-D Les marques melange
ACTO-D Formule chimique
C62H86N12O16
ACTO-D RX lien
http://www.rxlist.com/cgi/generic2/dactinomycin.htm
ACTO-D FDA fiche
ACTO-D msds (fiche de securite des materiaux)
ACTO-D Synthese de reference
Brockmann et al; Chem.Ber;. 93; 2971,2975 (1960)
ACTO-D Poids moleculaire
1255.42 g/mol
ACTO-D Point de fusion
241.5 - 243 oC
ACTO-D H2O Solubilite
Soluble à 10 ° C
ACTO-D Etat
solid
ACTO-D LogP
0.517
ACTO-D Formes pharmaceutiques
Solution injectable et parentérale
ACTO-D Indication
Pour le traitement des rhabdomyosarcomes Wilms tumorale enfance, le sarcome d'Ewing et métastatique, cancer du testicule non séminomateuses le cadre d'une chimiothérapie d'association et / ou de schéma de traitement multi-modalité
ACTO-D Pharmacologie
Généralement, le actinomycines exercent un effet inhibiteur sur les bactéries gram-positives et gram-négatives et sur certains champignons. Cependant, les propriétés toxiques de l'actinomycines (y compris dactinomycine) en relation à l'activité antibactérienne sont de nature à empêcher leur utilisation comme antibiotiques dans le traitement des maladies infectieuses. Parce que le actinomycines sont cytotoxiques, ils ont un effet antinéoplasique qui a été démontrée chez les animaux expérimentaux avec différents types d'implantation de la tumeur. Cette action cytotoxique est la base de leur utilisation dans le traitement de certains types de cancer. Dactinomycine est censé produire ses effets cytotoxiques par liaison à l'ADN et l'inhibition de synthèse d'ARN.
ACTO-D Absorption
mal absorbés par l'appareil gastro-intestinal
ACTO-D Toxicite
hépatotoxicité
ACTO-D Information pour les patients
Dactinomycin is a type of antibiotic that is only used in cancer
chemotherapy. It slows or stops the growth of cancer cells in your
body. The length of treatment depends on the types of drugs you are
taking, how well your body responds to them, and the type of cancer
you have. tell your doctor and pharmacist if you are allergic to
dactinomycin or any other drugs. tell your doctor and pharmacist
what prescription and nonprescription medications you are taking,
especially aspirin and vitamins. tell your doctor if you have or
have ever had liver disease, ulcers, or gastrointestinal disease.
you should know that dactinomycin may interfere with the normal
menstrual cycle (period) in women and may stop sperm production
in men. However, you should not assume that you cannot get pregnant
or that you cannot get someone else pregnant. Women who are pregnant
or breast-feeding should tell their doctors before they begin taking
this drug. You should not plan to have children while receiving
chemotherapy or for a while after treatments. (Talk to your doctor
for further details.) Use a reliable method of birth control to
prevent pregnancy. Dactinomycin may harm the fetus. do not have any
vaccinations (e.g., measles or flu shots) without talking to your
doctor.
chemotherapy. It slows or stops the growth of cancer cells in your
body. The length of treatment depends on the types of drugs you are
taking, how well your body responds to them, and the type of cancer
you have. tell your doctor and pharmacist if you are allergic to
dactinomycin or any other drugs. tell your doctor and pharmacist
what prescription and nonprescription medications you are taking,
especially aspirin and vitamins. tell your doctor if you have or
have ever had liver disease, ulcers, or gastrointestinal disease.
you should know that dactinomycin may interfere with the normal
menstrual cycle (period) in women and may stop sperm production
in men. However, you should not assume that you cannot get pregnant
or that you cannot get someone else pregnant. Women who are pregnant
or breast-feeding should tell their doctors before they begin taking
this drug. You should not plan to have children while receiving
chemotherapy or for a while after treatments. (Talk to your doctor
for further details.) Use a reliable method of birth control to
prevent pregnancy. Dactinomycin may harm the fetus. do not have any
vaccinations (e.g., measles or flu shots) without talking to your
doctor.
ACTO-D Organismes affectes
Les humains et autres mammifères
