Dilt-cd

• Vasodilator Agents
• Cardiovascular Agents
• Antihypertensive Agents
• Calcium-channel blocking agents
• ATC:C08DB01

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• Nu-Diltiaz
• Syn-Diltiazem
• Tiazac Tildiem
• d-cis-Diltiazem

No information avaliable

C₂₂H₂₆N₂O₄S

http://www.rxlist.com/cgi/generic/diltiaz.htm

Dilt-cd FDA

Dilt-cd MSDS

H. Kugita et al., Patente de EE.UU.. 3,562,257 (1971)

414.519 g/mol

231^oC

465 mg / L

Solid

3.141

Solución

Para el tratamiento de la hipertensión

Diltiazem, un benzotiazepina calcio-bloqueadores de los canales, se utiliza solo o con una conversión de la angiotensina inhibidor de la enzima, para tratar la hipertensión, angina de pecho crónica estable y angina de Prinzmetal variante. Diltiazem es similar a otros vasodilatadores periféricos. Diltiazem inhibe el influjo de calcio extracelular a través del miocardio y vascular membranas de células musculares lisas, posiblemente, por deformación de la canal, el control de la inhibición de los mecanismos de ion-gating, y / o interferir con la liberación de calcio desde el retículo sarcoplásmico. La disminución en el calcio intracelular inhibe los procesos de contracción de las células musculares lisas de miocardio, causando la dilatación de las arterias coronarias y sistémicas, el aumento de aporte de oxígeno al tejido miocárdico, disminución de la resistencia periférica total, disminución sistémica la presión arterial y disminución de la poscarga.

Diltiazem se absorbe bien en el tracto gastrointestinal, pero sufre hepática importante efecto de primer paso.

LD50 = 740mg/kg (por vía oral en ratones)

PATIENT INFORMATION

Take this medicine exactly as directed even if you feel well and do not notice any signs of chest pain.

Do not take more of this medicine and do not take it more often than your doctor ordered.

Do not miss any doses.

Diltiazem is a calcium channel blocking agents. For the calcium channel blocking agents, the following should be considered:

-Tell your doctor if you have ever had any unusual or allergic reaction to amlodipine, bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, or verapamil. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

-Calcium channel blocking agents have not been studied in pregnant women. However, studies in animals have shown that large doses of calcium channel blocking agents cause birth defects, prolonged pregnancy, poor bone development in the offspring, and stillbirth.

-Although bepridil, diltiazem, nifedipine, verapamil, and possibly other calcium channel blocking agents, pass into breast milk, they have not been reported to cause problems in nursing babies.

-Although there is no specific information comparing use of this medicine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.

-Elderly people may be especially sensitive to the effects of calcium channel blocking agents. This may increase the chance of side effects during treatment. A lower starting dose may be required.

-The presence of other medical problems may affect the use of the calcium channel blocking agents. Make sure you tell your doctor if you have any other medical problems, especially

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Humanos y otros mamíferos