Categoria
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Nombres de marca,
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Analogos
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Marca los nombres de mezcla
No information avaliable
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Formula quimica
C9H15NO3S
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RX enlace
http://www.rxlist.com/cgi/generic/captop.htm
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FDA hoja
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MSDS (hoja de seguridad de materiales)
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Sintesis de referencia
DW Cushman, EE.UU. Pat. 4,046,889 (1977)
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Peso molecular
217.286 g/mol
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Punto de fusion
106oC
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H2O Solubilidad
Muy soluble
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Estado
Solid
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LogP
0.546
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Formas de dosificacion
Tablet (12,5 mg, 25 mg, 50 mg o 100 mg)
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Indicacion
Para el tratamiento de la hipertensión. Se puede utilizar solo o en combinación con diuréticos tiazídicos.
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Farmacologia
Captopril, un inhibidor de la enzima convertidora de angiotensina (ECA), se utiliza para tratar la hipertensión, insuficiencia cardiaca congestiva, y síndromes renales como la nefropatía diabética y la esclerodermia. El efecto adverso y las limitaciones farmacocinéticas del captopril estimulado el desarrollo de inhibidores de la ECA enalapril y posteriores.
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Absorcion
75% sin alimentos (la presencia de alimentos en el tracto gastrointestinal reduce la absorción de unos 30 a 40 por ciento).
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Toxicidad
Los síntomas de sobredosis incluyen coma, letargo, baja presión arterial, la lentitud, y el estómago e irritación intestinal y la hiperactividad.
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Informacion de Pacientes
Patients should be advised to immediately report to their physician any signs or symptoms suggesting angioedema
(e.g., swelling of face, eyes, lips, tongue, larynx and extremities; difficulty in swallowing or breathing;
hoarseness) and to discontinue therapy.
Patients should be told to report promptly any indication of infection (e.g., sore throat, fever),which may be a
sign of neutropenia, or of progressive edema which might be related to proteinuria and nephrotic syndrome.
All patients should be cautioned that excessive perspiration and dehydration may lead to an excessive fall in
blood pressure because of reduction in fluid volume. Other causes of volume depletion such as vomiting or diarrhea
may also lead to a fall in blood pressure; patients should be advised to consult with the physician.
Patients should be advised not to use potassium-sparing diuret-ics, potassium supplements or potassium-containing
salt substitutes without consulting their physician.
Patients should be warned against interruption or discontinuation of medication unless instructed by the
physician.
Heart failure patients on captopril therapy should be cautioned against rapid increases in physical activity.
Patients should be informed that captopril should be taken one hour before meals.
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Organismos afectados
Humanos y otros mamíferos