Dianhydrosorbitol 2,5-dinitrate
Categoria
Dianhydrosorbitol 2,5-dinitrate Nombres de marca, Dianhydrosorbitol 2,5-dinitrate Analogos
- Cardio 10
- Cardis
- Carvanil
- Carvasin
- Cedocard
- Claodical
- Cornilat
- Coronex
- Corosorbide
- Dianhydrosorbitol 2,5-dinitrate
- Difutrat
- Dilatrate
- Dilatrate-SR
- Dinitrosorbide
- Emoper
- Flindix
- Harrical
- IBD 20
- ISD
- ISDN
- Ismotic
- Iso-Bid
- Isochron
- Isoket
- Isorbid;
- Isordil
- Isordil Tembids
- Isosorbide dinitrate(USAN)
- Isostat
- Isotrate
- Korodil
- Lomilan
- Maycor
- Myorexon
- Nitrosorbid
- Nitrosorbide
- Nitrosorbon
- Nosim
- Resoidan
- Rifloc Retard
- Rigedal
- Sorbangil
- Sorbide T.D.
- Sorbide nitrate
- Sorbide, dinitrate
- Sorbidilat
- Sorbidnitrate
- Sorbislo
- Sorbitrate
- Sorbonit
- Sorquad
- Tinidil
- Titradose
- Vascardin
- Vasodilat
- Vasorbate
- Xanyl
Dianhydrosorbitol 2,5-dinitrate Marca los nombres de mezcla
Dianhydrosorbitol 2,5-dinitrate Formula quimica
C6H8N2O8
Dianhydrosorbitol 2,5-dinitrate RX enlace
http://www.rxlist.com/cgi/generic2/isodinit.htm
Dianhydrosorbitol 2,5-dinitrate FDA hoja
Dianhydrosorbitol 2,5-dinitrate MSDS (hoja de seguridad de materiales)
Dianhydrosorbitol 2,5-dinitrate Sintesis de referencia
Goldberg, Acta Physiol. Scand.15, 173 (1948)
Dianhydrosorbitol 2,5-dinitrate Peso molecular
236.136 g/mol
Dianhydrosorbitol 2,5-dinitrate Punto de fusion
70 oC
Dianhydrosorbitol 2,5-dinitrate H2O Solubilidad
1.089 mg / mL
Dianhydrosorbitol 2,5-dinitrate Estado
Solid
Dianhydrosorbitol 2,5-dinitrate LogP
-0.53
Dianhydrosorbitol 2,5-dinitrate Formas de dosificacion
Tableta oral
Dianhydrosorbitol 2,5-dinitrate Indicacion
Para la prevención de la angina de pecho debido a enfermedad arterial coronaria.
Dianhydrosorbitol 2,5-dinitrate Farmacologia
Dinitrato de isosorbida es de moderado a nitrato de acción prolongada por vía oral orgánicos utilizados para el alivio y tratamiento profiláctico de la angina de pecho. Se relaja el músculo liso vascular y la dilatación consecuente de las arterias y venas periféricas, especialmente este último. Dilatación de las venas periféricas promueve la acumulación de sangre y disminuye el retorno venoso al corazón, reduciendo así ventricular izquierda diastólica final la presión y la presión capilar pulmonar (precarga). Relajación arteriolar disminuye la resistencia vascular sistémica, presión arterial sistólica y la presión arterial media.
Dianhydrosorbitol 2,5-dinitrate Absorcion
La absorción de dinitrato tras la administración oral es casi completa, pero la biodisponibilidad es muy variable (10% a 90%), con importante efecto de primer paso metabólico en el hígado. La biodisponibilidad media de dinitrato de isosorbida es aproximadamente un 25%.
Dianhydrosorbitol 2,5-dinitrate Toxicidad
Los síntomas de sobredosis incluyen disminución del gasto cardíaco e hipotensión.
Dianhydrosorbitol 2,5-dinitrate Informacion de Pacientes
PATIENT INFORMATION
Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.
Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol
Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related
to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In
particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients
who get these headaches, the headaches are a marker of the activity of the drug. Patients should
resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide
dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy.
Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-
induced headaches with no deleterious effect an isosorbide dinitrate's anti-anginal efficacy.
Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially
just after rising from a recumbent or seated position. This effect may be more frequent in patients
who have also consumed alcohol
Dianhydrosorbitol 2,5-dinitrate Organismos afectados
Humanos y otros mamíferos
