Dactinomycin

• Antibiotics
• Anti-bacterial Agents
• Antineoplastic Agents
• ATC:L01DA01

• ACT
• ACT D
• ACTINOMYCIN D
• ACTO-D
• AD
• Actactinomycin a Iv
• Actinomycin 11 Cosmegen
• Actinomycin 7
• Actinomycin Aiv
• Actinomycin C1
• Actinomycin I
• Actinomycin I1
• Actinomycin Iv
• Actinomycin X 1
• Actinomycindioic D Acid, Dilactone
• Antibiotic From Streptomyces Parvullus
• Chounghwamycin B
• Cosmegen
• Dactinomicina [Inn-Spanish]
• Dactinomycin D
• Dactinomycin [Usan:Ban]
• Dactinomycine [Inn-French]
• Dactinomycinum [Inn-Latin]
• Dilactone Actinomycin D Acid
• Dilactone Actinomycindioic D Acid
• Hbf 386 Meractinomycin
• Lyovac Cosmegen
• Meractinomycin
• Oncostatin K
• Oxamide

No information avaliable

C₆₂H₈₆N₁₂O₁₆

http://www.rxlist.com/cgi/generic2/dactinomycin.htm

Brockmann et al; Chem.Ber;. 93, 2971,2975 (1960)

1255.42 g/mol

241.5 - 243 ^oC

Solubles a 10 ° C

solid

0.517

Solución inyectable y parenteral

Para el tratamiento del rabdomiosarcoma de Wilms niños con tumores, el sarcoma de Ewing y el cáncer metastásico, el cáncer testicular no seminomatoso, como parte de una combinación de quimioterapia y / o multi-modalidad de régimen de tratamiento

En general, el actinomicinas ejercer un efecto inhibitorio sobre las bacterias gram-positivas y gram-negativas y en algunos hongos. Sin embargo, las propiedades tóxicas de la actinomicinas (incluyendo dactinomicina) en relación a la actividad antibacteriana son tales que se evite su uso como antibióticos en el tratamiento de las enfermedades infecciosas. Debido a que el actinomicinas son citotóxicos, que tienen un efecto antineoplásico que ha ha demostrado en animales de experimentación con diferentes tipos de implantes tumorales. Esta acción citotóxica es la base para su uso en el tratamiento de ciertos tipos de cáncer. Dactinomicina se cree que producir sus efectos citotóxicos de unión al ADN y la inhibición de la síntesis de ARN.

absorbe bien desde el tracto gastrointestinal

hepatotoxicidad

Dactinomycin is a type of antibiotic that is only used in cancer
chemotherapy. It slows or stops the growth of cancer cells in your
body. The length of treatment depends on the types of drugs you are
taking, how well your body responds to them, and the type of cancer
you have. tell your doctor and pharmacist if you are allergic to
dactinomycin or any other drugs. tell your doctor and pharmacist
what prescription and nonprescription medications you are taking,
especially aspirin and vitamins. tell your doctor if you have or
have ever had liver disease, ulcers, or gastrointestinal disease.
you should know that dactinomycin may interfere with the normal
menstrual cycle (period) in women and may stop sperm production
in men. However, you should not assume that you cannot get pregnant
or that you cannot get someone else pregnant. Women who are pregnant
or breast-feeding should tell their doctors before they begin taking
this drug. You should not plan to have children while receiving
chemotherapy or for a while after treatments. (Talk to your doctor
for further details.) Use a reliable method of birth control to
prevent pregnancy. Dactinomycin may harm the fetus. do not have any
vaccinations (e.g., measles or flu shots) without talking to your
doctor.

Humanos y otros mamíferos