delta-Aminolevulinic acid
delta-Aminolevulinic acid Brand names, delta-Aminolevulinic acid Analogs
delta-Aminolevulinic acid Brand Names Mixture
- No information avaliable
delta-Aminolevulinic acid Chemical_Formula
C5H9NO3
delta-Aminolevulinic acid RX_link
http://www.rxlist.com/cgi/generic3/levulan.htm
delta-Aminolevulinic acid fda sheet
delta-Aminolevulinic acid msds (material safety sheet)
delta-Aminolevulinic acid Synthesis Reference
No information avaliable
delta-Aminolevulinic acid Molecular Weight
131.13 g/mol
delta-Aminolevulinic acid Melting Point
156-158 oC
delta-Aminolevulinic acid H2O Solubility
Very soluble
delta-Aminolevulinic acid State
Solid
delta-Aminolevulinic acid LogP
-1.363
delta-Aminolevulinic acid Dosage Forms
Two component system consisting of a plastic tube containing two sealed glass ampules and an applicator tip (one ampule contains 1.5 mL of solution vehicle, the other ampule contains 354 mg of aminolevulinic acid hcl as a dry solid)
delta-Aminolevulinic acid Indication
Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.
delta-Aminolevulinic acid Pharmacology
The metabolism of aminolevulinic acid (ALA) is the first step in the biochemical pathway resulting in heme synthesis. Aminolevulinic acid is not a photosensitizer, but rather a metabolic precursor of protoporphyrin IX (PpIX), which is a photosensitizer. The synthesis of ALA is normally tightly controlled by feedback inhibition of the enzyme, ALA synthetase, presumably by intracellular heme levels. ALA, when provided to the cell, bypasses this control point and results in the accumulation of PpIX, which is converted into heme by ferrochelatase through the addition of iron to the PpIX nucleus.
delta-Aminolevulinic acid Absorption
Oral bioavailability is 50-60%.
delta-Aminolevulinic acid side effects and Toxicity
Solution overdose have not been reported.
delta-Aminolevulinic acid Patient Information
delta-Aminolevulinic acid Organisms Affected
Humans and other mammals
