Levulan Kerastick
Levulan Kerastick Brand names, Levulan Kerastick Analogs
Levulan Kerastick Brand Names Mixture
- No information avaliable
Levulan Kerastick Chemical_Formula
C5H9NO3
Levulan Kerastick RX_link
http://www.rxlist.com/cgi/generic3/levulan.htm
Levulan Kerastick fda sheet
Levulan Kerastick msds (material safety sheet)
Levulan Kerastick Synthesis Reference
No information avaliable
Levulan Kerastick Molecular Weight
131.13 g/mol
Levulan Kerastick Melting Point
156-158 oC
Levulan Kerastick H2O Solubility
Very soluble
Levulan Kerastick State
Solid
Levulan Kerastick LogP
-1.363
Levulan Kerastick Dosage Forms
Two component system consisting of a plastic tube containing two sealed glass ampules and an applicator tip (one ampule contains 1.5 mL of solution vehicle, the other ampule contains 354 mg of aminolevulinic acid hcl as a dry solid)
Levulan Kerastick Indication
Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.
Levulan Kerastick Pharmacology
The metabolism of aminolevulinic acid (ALA) is the first step in the biochemical pathway resulting in heme synthesis. Aminolevulinic acid is not a photosensitizer, but rather a metabolic precursor of protoporphyrin IX (PpIX), which is a photosensitizer. The synthesis of ALA is normally tightly controlled by feedback inhibition of the enzyme, ALA synthetase, presumably by intracellular heme levels. ALA, when provided to the cell, bypasses this control point and results in the accumulation of PpIX, which is converted into heme by ferrochelatase through the addition of iron to the PpIX nucleus.
Levulan Kerastick Absorption
Oral bioavailability is 50-60%.
Levulan Kerastick side effects and Toxicity
Solution overdose have not been reported.
Levulan Kerastick Patient Information
Levulan Kerastick Organisms Affected
Humans and other mammals
