Aladerm
Aladerm Brand names, Aladerm Analogs
Aladerm Brand Names Mixture
- No information avaliable
Aladerm Chemical_Formula
C5H9NO3
Aladerm RX_link
http://www.rxlist.com/cgi/generic3/levulan.htm
Aladerm fda sheet
Aladerm msds (material safety sheet)
Aladerm Synthesis Reference
No information avaliable
Aladerm Molecular Weight
131.13 g/mol
Aladerm Melting Point
156-158 oC
Aladerm H2O Solubility
Very soluble
Aladerm State
Solid
Aladerm LogP
-1.363
Aladerm Dosage Forms
Two component system consisting of a plastic tube containing two sealed glass ampules and an applicator tip (one ampule contains 1.5 mL of solution vehicle, the other ampule contains 354 mg of aminolevulinic acid hcl as a dry solid)
Aladerm Indication
Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.
Aladerm Pharmacology
The metabolism of aminolevulinic acid (ALA) is the first step in the biochemical pathway resulting in heme synthesis. Aminolevulinic acid is not a photosensitizer, but rather a metabolic precursor of protoporphyrin IX (PpIX), which is a photosensitizer. The synthesis of ALA is normally tightly controlled by feedback inhibition of the enzyme, ALA synthetase, presumably by intracellular heme levels. ALA, when provided to the cell, bypasses this control point and results in the accumulation of PpIX, which is converted into heme by ferrochelatase through the addition of iron to the PpIX nucleus.
Aladerm Absorption
Oral bioavailability is 50-60%.
Aladerm side effects and Toxicity
Solution overdose have not been reported.
Aladerm Patient Information
Aladerm Organisms Affected
Humans and other mammals
