Levulan
Levulan Brand names, Levulan Analogs
Levulan Brand Names Mixture
- No information avaliable
Levulan Chemical_Formula
C5H9NO3
Levulan RX_link
http://www.rxlist.com/cgi/generic3/levulan.htm
Levulan fda sheet
Levulan msds (material safety sheet)
Levulan Synthesis Reference
No information avaliable
Levulan Molecular Weight
131.13 g/mol
Levulan Melting Point
156-158 oC
Levulan H2O Solubility
Very soluble
Levulan State
Solid
Levulan LogP
-1.363
Levulan Dosage Forms
Two component system consisting of a plastic tube containing two sealed glass ampules and an applicator tip (one ampule contains 1.5 mL of solution vehicle, the other ampule contains 354 mg of aminolevulinic acid hcl as a dry solid)
Levulan Indication
Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.
Levulan Pharmacology
The metabolism of aminolevulinic acid (ALA) is the first step in the biochemical pathway resulting in heme synthesis. Aminolevulinic acid is not a photosensitizer, but rather a metabolic precursor of protoporphyrin IX (PpIX), which is a photosensitizer. The synthesis of ALA is normally tightly controlled by feedback inhibition of the enzyme, ALA synthetase, presumably by intracellular heme levels. ALA, when provided to the cell, bypasses this control point and results in the accumulation of PpIX, which is converted into heme by ferrochelatase through the addition of iron to the PpIX nucleus.
Levulan Absorption
Oral bioavailability is 50-60%.
Levulan side effects and Toxicity
Solution overdose have not been reported.
Levulan Patient Information
Levulan Organisms Affected
Humans and other mammals
