Kerastick
Kerastick Brand names, Kerastick Analogs
Kerastick Brand Names Mixture
- No information avaliable
Kerastick Chemical_Formula
C5H9NO3
Kerastick RX_link
http://www.rxlist.com/cgi/generic3/levulan.htm
Kerastick fda sheet
Kerastick msds (material safety sheet)
Kerastick Synthesis Reference
No information avaliable
Kerastick Molecular Weight
131.13 g/mol
Kerastick Melting Point
156-158 oC
Kerastick H2O Solubility
Very soluble
Kerastick State
Solid
Kerastick LogP
-1.363
Kerastick Dosage Forms
Two component system consisting of a plastic tube containing two sealed glass ampules and an applicator tip (one ampule contains 1.5 mL of solution vehicle, the other ampule contains 354 mg of aminolevulinic acid hcl as a dry solid)
Kerastick Indication
Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.
Kerastick Pharmacology
The metabolism of aminolevulinic acid (ALA) is the first step in the biochemical pathway resulting in heme synthesis. Aminolevulinic acid is not a photosensitizer, but rather a metabolic precursor of protoporphyrin IX (PpIX), which is a photosensitizer. The synthesis of ALA is normally tightly controlled by feedback inhibition of the enzyme, ALA synthetase, presumably by intracellular heme levels. ALA, when provided to the cell, bypasses this control point and results in the accumulation of PpIX, which is converted into heme by ferrochelatase through the addition of iron to the PpIX nucleus.
Kerastick Absorption
Oral bioavailability is 50-60%.
Kerastick side effects and Toxicity
Solution overdose have not been reported.
Kerastick Patient Information
Kerastick Organisms Affected
Humans and other mammals
