PharmacyCodes



alpha-Carboxybenzylpencillin en es it fr

alpha-Carboxybenzylpencillin Brand names, alpha-Carboxybenzylpencillin Analogs

alpha-Carboxybenzylpencillin Brand Names Mixture

  • No information avaliable

alpha-Carboxybenzylpencillin Chemical_Formula

C17H18N2O6S

alpha-Carboxybenzylpencillin RX_link

http://www.rxlist.com/cgi/generic3/geocillin.htm

alpha-Carboxybenzylpencillin fda sheet

alpha-Carboxybenzylpencillin msds (material safety sheet)

alpha-Carboxybenzylpencillin MSDS

alpha-Carboxybenzylpencillin Synthesis Reference

No information avaliable

alpha-Carboxybenzylpencillin Molecular Weight

378.401 g/mol

alpha-Carboxybenzylpencillin Melting Point

No information avaliable

alpha-Carboxybenzylpencillin H2O Solubility

451 mg/L

alpha-Carboxybenzylpencillin State

Solid

alpha-Carboxybenzylpencillin LogP

1.216

alpha-Carboxybenzylpencillin Dosage Forms

Tablets containing 382 mg carbenicillin (for oral use)

alpha-Carboxybenzylpencillin Indication

For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.

alpha-Carboxybenzylpencillin Pharmacology

Carbenicillin is a semisynthetic penicillin. Though carbenicillin provides substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal activity. Because of the high urine levels obtained following administration, carbenicillin has demonstrated clinical efficacy in urinary infections due to susceptible strains of: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Pseudomonas species, Providencia rettgeri, Enterobacter species, and Enterococci (S. faecalis).

alpha-Carboxybenzylpencillin Absorption

Acid stable, and rapidly absorbed from the small intestine following oral administration.

alpha-Carboxybenzylpencillin side effects and Toxicity

Carbenicillin blood levels achievable are very low, and toxic reactions as a function of overdosage should not occur systematically. The oral LD50 in mice is 3,600 mg/kg, in rats 2,000 mg/kg, and in dogs is in excess of 500 mg/kg. The lethal human dose is not known. Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.

alpha-Carboxybenzylpencillin Patient Information

No information avaliable

alpha-Carboxybenzylpencillin Organisms Affected

Enteric bacteria and other eubacteria