Pyopen
Pyopen Brand names, Pyopen Analogs
Pyopen Brand Names Mixture
- No information avaliable
Pyopen Chemical_Formula
C17H18N2O6S
Pyopen RX_link
http://www.rxlist.com/cgi/generic3/geocillin.htm
Pyopen fda sheet
Pyopen msds (material safety sheet)
Pyopen Synthesis Reference
No information avaliable
Pyopen Molecular Weight
378.401 g/mol
Pyopen Melting Point
No information avaliable
Pyopen H2O Solubility
451 mg/L
Pyopen State
Solid
Pyopen LogP
1.216
Pyopen Dosage Forms
Tablets containing 382 mg carbenicillin (for oral use)
Pyopen Indication
For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.
Pyopen Pharmacology
Carbenicillin is a semisynthetic penicillin. Though carbenicillin provides substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal activity. Because of the high urine levels obtained following administration, carbenicillin has demonstrated clinical efficacy in urinary infections due to susceptible strains of: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Pseudomonas species, Providencia rettgeri, Enterobacter species, and Enterococci (S. faecalis).
Pyopen Absorption
Acid stable, and rapidly absorbed from the small intestine following oral administration.
Pyopen side effects and Toxicity
Carbenicillin blood levels achievable are very low, and toxic reactions as a function of overdosage should not occur systematically. The oral LD50 in mice is 3,600 mg/kg, in rats 2,000 mg/kg, and in dogs is in excess of 500 mg/kg. The lethal human dose is not known. Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.
Pyopen Patient Information
No information avaliable
Pyopen Organisms Affected
Enteric bacteria and other eubacteria
