Carboxybenzylpenicillin acid
Carboxybenzylpenicillin acid Brand names, Carboxybenzylpenicillin acid Analogs
Carboxybenzylpenicillin acid Brand Names Mixture
- No information avaliable
Carboxybenzylpenicillin acid Chemical_Formula
C17H18N2O6S
Carboxybenzylpenicillin acid RX_link
http://www.rxlist.com/cgi/generic3/geocillin.htm
Carboxybenzylpenicillin acid fda sheet
Carboxybenzylpenicillin acid msds (material safety sheet)
Carboxybenzylpenicillin acid Synthesis Reference
No information avaliable
Carboxybenzylpenicillin acid Molecular Weight
378.401 g/mol
Carboxybenzylpenicillin acid Melting Point
No information avaliable
Carboxybenzylpenicillin acid H2O Solubility
451 mg/L
Carboxybenzylpenicillin acid State
Solid
Carboxybenzylpenicillin acid LogP
1.216
Carboxybenzylpenicillin acid Dosage Forms
Tablets containing 382 mg carbenicillin (for oral use)
Carboxybenzylpenicillin acid Indication
For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.
Carboxybenzylpenicillin acid Pharmacology
Carbenicillin is a semisynthetic penicillin. Though carbenicillin provides substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal activity. Because of the high urine levels obtained following administration, carbenicillin has demonstrated clinical efficacy in urinary infections due to susceptible strains of: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Pseudomonas species, Providencia rettgeri, Enterobacter species, and Enterococci (S. faecalis).
Carboxybenzylpenicillin acid Absorption
Acid stable, and rapidly absorbed from the small intestine following oral administration.
Carboxybenzylpenicillin acid side effects and Toxicity
Carbenicillin blood levels achievable are very low, and toxic reactions as a function of overdosage should not occur systematically. The oral LD50 in mice is 3,600 mg/kg, in rats 2,000 mg/kg, and in dogs is in excess of 500 mg/kg. The lethal human dose is not known. Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.
Carboxybenzylpenicillin acid Patient Information
No information avaliable
Carboxybenzylpenicillin acid Organisms Affected
Enteric bacteria and other eubacteria
