Geopen
Geopen Brand names, Geopen Analogs
Geopen Brand Names Mixture
- No information avaliable
Geopen Chemical_Formula
C17H18N2O6S
Geopen RX_link
http://www.rxlist.com/cgi/generic3/geocillin.htm
Geopen fda sheet
Geopen msds (material safety sheet)
Geopen Synthesis Reference
No information avaliable
Geopen Molecular Weight
378.401 g/mol
Geopen Melting Point
No information avaliable
Geopen H2O Solubility
451 mg/L
Geopen State
Solid
Geopen LogP
1.216
Geopen Dosage Forms
Tablets containing 382 mg carbenicillin (for oral use)
Geopen Indication
For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.
Geopen Pharmacology
Carbenicillin is a semisynthetic penicillin. Though carbenicillin provides substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal activity. Because of the high urine levels obtained following administration, carbenicillin has demonstrated clinical efficacy in urinary infections due to susceptible strains of: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Pseudomonas species, Providencia rettgeri, Enterobacter species, and Enterococci (S. faecalis).
Geopen Absorption
Acid stable, and rapidly absorbed from the small intestine following oral administration.
Geopen side effects and Toxicity
Carbenicillin blood levels achievable are very low, and toxic reactions as a function of overdosage should not occur systematically. The oral LD50 in mice is 3,600 mg/kg, in rats 2,000 mg/kg, and in dogs is in excess of 500 mg/kg. The lethal human dose is not known. Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.
Geopen Patient Information
No information avaliable
Geopen Organisms Affected
Enteric bacteria and other eubacteria
