Zefazone
Zefazone Brand names, Zefazone Analogs
Zefazone Brand Names Mixture
- No information avaliable
Zefazone Chemical_Formula
C15H17N7O5S3
Zefazone RX_link
No information avaliable
Zefazone fda sheet
Zefazone msds (material safety sheet)
Zefazone Synthesis Reference
No information avaliable
Zefazone Molecular Weight
471.538 g/mol
Zefazone Melting Point
No information avaliable
Zefazone H2O Solubility
94.2 mg/L
Zefazone State
No information avaliable
Zefazone LogP
-1.063
Zefazone Dosage Forms
Solution for injection
Zefazone Indication
For the treatment of infections caused by susceptible organisms.
Zefazone Pharmacology
Cefmetazole is a second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins. Cefmetazole is more active than 1st-generation cephalosporins against indole-positive Proteus, Serratia, anaerobic gram-negative bacilli (including B. fragilis), and some E. coli, Klebsiella, and P. mirabilis, but is less active than cefoxitin or cefotetan against most gram-negative bacilli.
Zefazone Absorption
Bioavailability is approximately 100% following intramuscular injection.
Zefazone side effects and Toxicity
Oral LD50 in rats is 3,204 mg/kg. With other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Zefazone Patient Information
No information avaliable
Zefazone Organisms Affected
Enteric bacteria and other eubacteria
