Zefazone In Plastic Container
Brand names,
Zefazone In Plastic Container
Analogs
Zefazone In Plastic Container
Brand Names Mixture
Zefazone In Plastic Container
Chemical_Formula
C15H17N7O5S3
Zefazone In Plastic Container
RX_link
No information avaliable
Zefazone In Plastic Container
fda sheet
Zefazone In Plastic Container
msds (material safety sheet)
Zefazone In Plastic Container
Synthesis Reference
No information avaliable
Zefazone In Plastic Container
Molecular Weight
471.538 g/mol
Zefazone In Plastic Container
Melting Point
No information avaliable
Zefazone In Plastic Container
H2O Solubility
94.2 mg/L
Zefazone In Plastic Container
State
No information avaliable
Zefazone In Plastic Container
LogP
-1.063
Zefazone In Plastic Container
Dosage Forms
Solution for injection
Zefazone In Plastic Container
Indication
For the treatment of infections caused by susceptible organisms.
Zefazone In Plastic Container
Pharmacology
Cefmetazole is a second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins. Cefmetazole is more active than 1st-generation cephalosporins against indole-positive Proteus, Serratia, anaerobic gram-negative bacilli (including B. fragilis), and some E. coli, Klebsiella, and P. mirabilis, but is less active than cefoxitin or cefotetan against most gram-negative bacilli.
Zefazone In Plastic Container
Absorption
Bioavailability is approximately 100% following intramuscular injection.
Zefazone In Plastic Container
side effects and Toxicity
Oral LD50 in rats is 3,204 mg/kg. With other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Zefazone In Plastic Container
Patient Information
No information avaliable
Zefazone In Plastic Container
Organisms Affected
Enteric bacteria and other eubacteria