UPJOHN CO THE -- 51871 ZEFAZONE IV SOLUTION -- 6505-00F038039
===================== Product Identification =====================
Product ID:51871 ZEFAZONE IV SOLUTION
MSDS Date:06/30/1994
FSC:6505
NIIN:00F038039
MSDS Number: BWKMC
=== Responsible Party ===
Company Name:UPJOHN CO THE
Address:7171 PORTAGE RD
City:KALAMAZOO
State:MI
ZIP:49001-0199
Country:US
Info Phone Num:616-385-7358
Emergency Phone Num:616-323-7555(D)/616-323-5122(24 HR)
CAGE:GO374
=== Contractor Identification ===
Company Name:PHARMACIA & UPJOHN
Address:7171 PORTAGE RD
Box:City:KALAMAZOO
State:MI
ZIP:49001-0199
Country:US
Phone:616-833-5122/616-833-7555
CAGE:93703
Company Name:UPJOHN CO THE
Address:7171 PORTAGE RD
City:KALAMAZOO
State:MI
ZIP:49001-0199
Country:US
Phone:616-323-7555
CAGE:GO374
============= Composition/Information on Ingredients =============
Ingred Name:WATER
CAS:7732-18-5
RTECS #:ZC0110000
Fraction by Wt: <95%
Ingred Name:NON HAZARDOUS INGREDIENTS
Ingred Name:CEFMETAZOLE SODIUM *94-4*
CAS:56796-39-5
RTECS #:XI0372200
Fraction by Wt: 2-4%
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50(RAT): 3,204 MG/KG (SEE SUPP)
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:OVEREXPOSURE TO CEFMETAZOLE SOIUM
COULD CAUSE MILD TO SEVERE ALLERGIC
REACTIONS/BRONCHOSPASM/ANGIOEDEMA & ANAPHYLAXIS. ALLERGIC REACTIONS
INCLUDE STEVENS-JOHNSON SYNDROME & ERYTHEMA MULTIFORME. GASTRO
INTESTINAL EFFECTS. PSEUDOMEMBRANOUS COLITIS MAY RANGE IN SEVERITY
FROM MILD TO LIFE THREATENING.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:RASH, FEVER, SWELLING, ASTHMATIC BREAHTING,
HIVES, NAUSEA, VOMITING, DIARRHEA
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO
CEFMETAZOLE/CEPHALOSPORIN GROUP OF ANTIBIOTICS, BETA-LACTAM
ANTIBIOTICS, RENAL/HEPTATIC IMPAIRMENT, POOR NUTRITIONAL STATE/GI
DISEASE/CURRENTLY BEING TREATED W/AN AMINOGLYCOSIDE.
======================= First Aid Measures =======================
First Aid:EYES: FLUSH W/WATER FOR 15 MINS. SKIN: WASH W/SOAP & WATER.
INHALATION: REMOVE FROM EXPOSURE. OBTAIN MEDICAL ATTENTION IN ALL
CASES. NOTES TO PHYSICIAN: IN THE EVENT OF SERIOUS TOXIC REACTIONS
FROM OV EREXPOSURE, HEMODIALYSIS/PERITONEAL DIALYSIS MAY AID IN THE
REMOVAL OF CEFMETAZOLE FROM THE BODY, ESPECIALLY IF RENAL FUNCTION
IS COMPROMISED.
===================== Fire Fighting Measures =====================
Flash Point:NONFLAMMABLE
Extinguishing Media:WATER, CO2/DRY CHEMICAL
Fire Fighting Procedures:WEAR SELF CONTAINED BREAHTING APPARATUS & FULL
BODY PROTECTIVE EQUIPMENT.
Unusual Fire/Explosion Hazard:NONE
================== Accidental Release Measures ==================
Spill Release Procedures:PROVIDE VENTILATION & PERSONAL PROTECTION.
KEEP PRODUCT OUT OF DRAINS; PREVENT ENTRY TO SURFACE
WATER/GROUNDWATER & SOIL. SMALL: ABSORB W/PAPER TOWELS/OTHER
APPROPRIATE MEDIA. LARGE: VACUUM/SCOOP & PL ACE IN A SUITABLE
CONTAINER.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE IN A COOL, DRY PLACE & PROTECT
FROM LIGHT. THE UNDILUTED PRODUCT SHOULD BE STORED IN A CONSTANT
FREEZER AT -4F.
Other Precautions:KEEP OUT OF REACH OF CHILDREN. AVOID CONTACT W/SKIN,
EYES & CLOTHING.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:NOT REQUIRED.
Ventilation:LOCAL EXHAUST.
Protective Gloves:RUBBER.
Eye Protection:SAFETY GLASSES W/SIDE SHIELDS.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
ZEFAZONE IV SOLUTION IS A HUMAN DRUG USED IN THE TREATMENT OF SERIOUS
INFECTIONS INVOLVING THE URINARY TRACT, LOWER RESPITORY TRACT,
SKIN/SUPPORTING STRUCTURES, INTRAABDOMINAL INFECTIONS & SOME SEXUAL
LY TRANSMITTED DISEASES. PH: 4.2-6.2 (THAWED). ORAL LD50
INFORMATION IS FOR: CEFMETAZOLE SODIUM.
================== Physical/Chemical Properties ==================
pH:(SUPP)
Solubility in Water:COMPLETE
Appearance and Odor:FROZEN, PREMIXED SOLUTION (W/1-2 G CEFMETAZOLE
SODIUM) IN 50 ML PLASTIC BAGS.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
NONE
Stability Condition to Avoid:THAWED- >21 DAYS AT TEMP >46F/>48 HOURS AT
TEMP >77F.
Hazardous Decomposition Products:CO, CO2, NITROGEN OXIDES, SULFUR
OXIDES.
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF BY INCINERATION IN ACCORDANCE
W/LOCAL, STATE & FEDERAL REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.