Xigris (Eli Lilly & Co)
Brand names,
Xigris (Eli Lilly & Co)
Analogs
Xigris (Eli Lilly & Co)
Brand Names Mixture
Xigris (Eli Lilly & Co)
Chemical_Formula
C1786H2779N509O519S29
Xigris (Eli Lilly & Co)
RX_link
http://www.rxlist.com/cgi/generic/drotrecogin.htm
Xigris (Eli Lilly & Co)
fda sheet
Xigris (Eli Lilly & Co)
msds (material safety sheet)
Xigris (Eli Lilly & Co)
Synthesis Reference
No information avaliable
Xigris (Eli Lilly & Co)
Molecular Weight
55000
Xigris (Eli Lilly & Co)
Melting Point
No information avaliable
Xigris (Eli Lilly & Co)
H2O Solubility
No information avaliable
Xigris (Eli Lilly & Co)
State
Liquid
Xigris (Eli Lilly & Co)
LogP
-0.291
Xigris (Eli Lilly & Co)
Dosage Forms
Powder for solution
Xigris (Eli Lilly & Co)
Indication
For treatment of severe sepsis
Xigris (Eli Lilly & Co)
Pharmacology
Activated Protein C exerts an antithrombotic effect by inhibiting (cleaving) Factors Va and VIIIa. In vitro data indicate that Activated Protein C has indirect profibrinolytic activity through its ability to inhibit plasminogen activator inhibitor-1 (PAI-1) and limiting generation of activated thrombin-activatable-fibrinolysis-inhibitor. The net effect is the reduction or elimination of blood clots
Xigris (Eli Lilly & Co)
Absorption
No information avaliable
Xigris (Eli Lilly & Co)
side effects and Toxicity
No information avaliable
Xigris (Eli Lilly & Co)
Patient Information
No information avaliable
Xigris (Eli Lilly & Co)
Organisms Affected
Humans and other mammals