Trifluoromethylhydrothiazide
Trifluoromethylhydrothiazide Brand names, Trifluoromethylhydrothiazide Analogs
- Bristab
- Bristurin
- Di-ademil
- Dihydroflumethazide
- Dihydroflumethiazide
- Dioxotrifluoromethyltetrahydrobenzothiadiazinesulfonamide
- Diucardin
- Diuredemina
- Diurometon
- Elodrine
- Enjit
- Finuret
- Flutizide
- Glomerulin
- Hidroalogen
- Hidroflumetiazid
- Hydol
- Hydrenox
- Hydroflumethazide
- Hydroflumethizide
- Leodrine
- Metflorylthiazidine
- Methforylthiazidine
- NaClex
- Olmagran
- Robezon
- Rodiuran
- Rontyl
- Saluron
- Sisuril
- Spandiuril
- Trifluoromethylhydrazide
- Trifluoromethylhydrothiazide
- Vergonil
Trifluoromethylhydrothiazide Brand Names Mixture
- No information avaliable
Trifluoromethylhydrothiazide Chemical_Formula
C8H8F3N3O4S2
Trifluoromethylhydrothiazide RX_link
http://www.rxlist.com/cgi/generic2/hydroflumethiazide.htm
Trifluoromethylhydrothiazide fda sheet
Trifluoromethylhydrothiazide msds (material safety sheet)
Trifluoromethylhydrothiazide Synthesis Reference
No information avaliable
Trifluoromethylhydrothiazide Molecular Weight
331.294 g/mol
Trifluoromethylhydrothiazide Melting Point
272 - 273 oC
Trifluoromethylhydrothiazide H2O Solubility
No information avaliable
Trifluoromethylhydrothiazide State
Solid
Trifluoromethylhydrothiazide LogP
0.108
Trifluoromethylhydrothiazide Dosage Forms
Tablets
Trifluoromethylhydrothiazide Indication
Used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Trifluoromethylhydrothiazide Pharmacology
Hydroflumethiazide is an oral thiazide used to treat hypertension and edema. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. Like other thiazides, Hydroflumethiazide promotes water loss from the body (diuretics). Thiazides inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Trifluoromethylhydrothiazide Absorption
Hydroflumethiazide is incompletely but fairly rapidly absorbed from the gastrointestinal tract
Trifluoromethylhydrothiazide side effects and Toxicity
Overdoses lead to diuresis, lethargy progressing to coma, with minimal cardiorespiratory depression and with or without significant serum electrolyte changes or dehydration.
Trifluoromethylhydrothiazide Patient Information
Trifluoromethylhydrothiazide Organisms Affected
Humans and other mammals
